Evidence map›Paper›PMID 34252527›Full record

ArticleNeuroImage2021

Structural and resting state functional connectivity beyond the cortex.

Olivia K Harrison, Xavier Guell, Miriam C Klein-Flügge, Robert L Barry

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Spinal Cord fMRI: A New Window into the Central Nervous System.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olivia K HarrisonSchool of Pharmacy, University of Otago, New Zealand; Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Switzerland; Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom. Electronic address: olivia.harrison@otago.ac.nz.
Xavier GuellMassachusetts General Hospital, Harvard Medical School, United States; Massachusetts Institute of Technology, United States.
Miriam C Klein-FlüggeWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, United Kingdom.
Robert L BarryAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, United States; Department of Radiology, Harvard Medical School, United States; Harvard-Massachusetts Institute of Technology Health Sciences & Technology, United States.

Funding

Spinal cord functional connectivity as a biomarker of spinal cord dysfunctionR01EB027779 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BARRY, ROBERT L · 2019 to 2022
$2.7M
Medical Research Council MR/P024955/1NIBIB NIH HHS R01 EB027779Wellcome TrustWellcome Trust 103184/Z/13/Z
6 · The paper itself

Abstract

Mapping the structural and functional connectivity of the central nervous system has become a key area within neuroimaging research. While detailed network structures across the entire brain have been probed using animal models, non-invasive neuroimaging in humans has thus far been dominated by cortical investigations. Beyond the cortex, subcortical nuclei have traditionally been less accessible due to their smaller size and greater distance from radio frequency coils. However, major neuroimaging developments now provide improved signal and the resolution required to study these structures. Here, we present an overview of the connectivity between the amygdala, brainstem, cerebellum, spinal cord and the rest of the brain. While limitations to their imaging and analyses remain, we also provide some recommendations and considerations for mapping brain connectivity beyond the cortex.

Indexed as

ConnectomeAmygdalaAnimalsBrain StemCerebellumDefault Mode NetworkDiffusion Tensor ImagingHumansMagnetic Resonance ImagingSignal-To-Noise RatioSpinal CordAmygdalaBrainstemCerebellumConnectivitySpinal cord

Identifiers

PMID34252527
PMCPMC8429261

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.