Evidence map›Paper›PMID 34252317›Full record

ArticleCurrent medical research and opinion2021

Comparing the downstream costs and healthcare utilization associated with the use of low-dose computed tomography (LDCT) in lung cancer screening in patients with and without alzheimer's disease and related dementias (ADRD).

Yahan Zhang, Jiang Bian, Jinhai Huo, Shuang Yang, Yi Guo, Hui Shao

Open access · greenAbstract read
In one paragraph

Article in Current medical research and opinion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yahan ZhangDepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Jiang BianDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.
Jinhai HuoUS Health Economics and Outcomes Research at Bristol-Myers Squibb, Princeton, NJ, USA.
Shuang YangDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.
Yi GuoDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.
Hui ShaoDepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA.
University of Florida · USUniversity of Florida Health · USBristol-Myers Squibb (United States) · US

Funding

The benefits and harms of lung cancer screening in FloridaR01CA246418 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2023
$1.7M
Using Real-world Data to Assess the Burden of Diabetes in Children and Adolescents in FloridaU18DP006512 · DP · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2024
$1.4M
Using Electronic Health Records from a Large Clinical Data Research Network to Understand Cancer Burden and Cancer Risks Among Transgender and Gender Nonconforming (TGNC) IndividualsR21CA245858 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2021
$773k
Optimizing the Population Representativeness of Older Adults in Alzheimer's Disease and Related Dementia Clinical TrialsR21AG068717 · NIA · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2021
$419k
Optimizing the Population Representativeness of Older Adults in Cancer TrialsR21CA253394 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2021 to 2021
$392k
ACL HHS U18DP006512NCCDPHP CDC HHS U18 DP006512NCI NIH HHS R01 CA246418NCI NIH HHS R21 CA245858NCI NIH HHS R21 CA253394NIA NIH HHS R21 AG068717
6 · The paper itself

Abstract

objectiveThis study aims to compare the downstream costs and healthcare utilization associated with using low-dose computed tomography (LDCT) for lung cancer screening in patients with and without Alzheimer's disease and related dementias (ADRD).

methodsBased on data from IBM MarketScan Commercial Claims Databases (2014-2018), we have identified four study cohorts: ADRD and non-ADRD patients who went through LDCT screening; ADRD and non-ADRD patients without LDCT screening. Annually healthcare utilization and cost were grouped into outpatient, inpatient, and pharmacy. We used difference-in-differences (DID) models to estimate the downstream healthcare utilization and cost associated with LDCT screening in both ADRD and non-ADRD population. We used a difference-in-difference-in-differences (DDD) model to explore whether LDCT screening was associated with higher downstream cost and healthcare utilization in ADRD population than non-ADRD population.

resultCompared to individuals without LDCT screening, LDCT screening was associated with increased outpatient visits (2.1, 95% CI 0.7, 3.4) and outpatient cost ($2301.0, 95% CI 296.2, 4305.8) in the ADRD population and increased outpatient visits (0.6, 95% CI 0.1, 1.1) in the non-ADRD population within 1 year after screening. Compared with the non-ADRD population, LDCT screening was found to be associated with an additional 1.5 (95% CI 0.2, 2.8) outpatient visits, 0.7 (95% CI 0.1, 1.3) days of inpatient stays, and $4,960.4 (95% CI 532.7, 9388.0) in overall healthcare costs within 1-year after LDCT in the ADRD population (all

conclusionThe downstream cost and healthcare utilization associated with LDCT screening were found to be higher in the ADRD population compared to the average population.

Indexed as

Alzheimer DiseaseLung NeoplasmsEarly Detection of CancerHumansPatient Acceptance of Health CareTomography, X-Ray ComputedAlzheimer’s disease and related dementiasexpenditureshealthcare utilizationlow-dose computed tomographyLung cancer screening

Identifiers

PMID34252317
PMCPMC8627644
OpenAlexW3180110722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.