Evidence map›Paper›PMID 34252310›Full record

ArticleAntimicrobial agents and chemotherapy2021

Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa.

Justyna W Adamiak, Varsha Jhawar, Vincent Bonifay, Courtney E Chandler, Inga V Leus, Robert K Ernst, Herbert P Schweizer, Helen I Zgurskaya

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Engineering low-endotoxin lipid A in a double auxotrophFrontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Functional interplay between RND efflux pumps and GacS inApplied and environmental microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Multidrug efflux pumps ofFrontiers in microbiology · 2024
    Article
  11. The Art of War withAntibiotics (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Impact of phage predation onRNA biology · 2023
    Article
  16. Review
  17. Role of Efflux Pumps on Antimicrobial Resistance inInternational journal of molecular sciences · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Justyna W AdamiakUniversity of Oklahomagrid.266900.b, Department of Chemistry and Biochemistry, Norman, Oklahoma, USA.
Varsha JhawarUniversity of Oklahomagrid.266900.b, Department of Chemistry and Biochemistry, Norman, Oklahoma, USA.
Vincent BonifayUniversity of Oklahomagrid.266900.b, Department of Chemistry and Biochemistry, Norman, Oklahoma, USA.
Courtney E ChandlerUniversity of Maryland, Baltimore, Department of Microbial Pathogenesis, Baltimore, Maryland, USA.
Inga V LeusUniversity of Oklahomagrid.266900.b, Department of Chemistry and Biochemistry, Norman, Oklahoma, USA.
Robert K ErnstUniversity of Maryland, Baltimore, Department of Microbial Pathogenesis, Baltimore, Maryland, USA.ORCID 0000-0001-5016-8694
Herbert P SchweizerNorthern Arizona University, Pathogen and Microbiome Institute, Flagstaff, Arizona, USA.ORCID 0000-0002-8847-335X
Helen I ZgurskayaUniversity of Oklahomagrid.266900.b, Department of Chemistry and Biochemistry, Norman, Oklahoma, USA.ORCID 0000-0001-8929-4727
University of Oklahoma · USUniversity of Maryland, Baltimore · USNorthern Arizona University · US

Funding

Permeability Barriers of Gram-negative Pathogens and Approaches to Bypass ThemR01AI132836 · NIAID · UNIVERSITY OF OKLAHOMA · PI HELEN I ZGURSKAYA · 2017 to 2026
$4.3M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI132836NIAID NIH HHS R01 AI132836
6 · The paper itself

Abstract

Transporters belonging to the

Indexed as

Lipid APseudomonas aeruginosaIronMembrane Transport ProteinsQuorum SensingIronLipid AMembrane Transport Proteinsantibiotic resistancelipid Amultidrug effluxPseudomonas aeruginosatranscriptomics

Identifiers

PMID34252310
PMCPMC8448130
OpenAlexW3181132012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.