Evidence map›Paper›PMID 34252282›Full record

ArticleThe journal of physical chemistry. B2021

Effects of the Hydrophilic N-Terminal Region on Aβ-Mediated Membrane Disruption.

Clifford Morris, Thomas W Kent, Fengyun Shen, Ewa P Wojcikiewicz, Deguo Du

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The p3 peptides (AβNature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Clifford MorrisDepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, United States.
Thomas W KentDepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, United States.
Fengyun ShenDepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, United States.
Ewa P WojcikiewiczDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431, United States.
Deguo DuDepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, United States.ORCID 0000-0002-8701-8208
Florida Atlantic University · US

Funding

Role of the N-terminal Region in Abeta Oligomer and Fibril FormationR15GM116006 · NIGMS · FLORIDA ATLANTIC UNIVERSITY · PI DU, DEGUO · 2015 to 2020
$735k
NIGMS NIH HHS R15 GM116006
6 · The paper itself

Abstract

Amyloidogenesis of amyloid-β (Aβ) peptides is intimately related to pathological neurodegeneration in Alzheimer's disease. Here, we investigated the membrane damage activity of Aβ40 and its derivatives that contain mutation at the N-terminal charged residues using a membrane leakage assay. A model 1,2-dipalmitoyl-

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesHumansPeptide FragmentsPhosphatidylcholinesStatic ElectricityAmyloid beta-PeptidesPeptide FragmentsPhosphatidylcholines

Identifiers

PMID34252282
PMCPMC9703304
OpenAlexW3178672442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.