Evidence map›Paper›PMID 34252260›Full record

ArticleStem cells (Dayton, Ohio)2021

Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair.

Jiajia Xu, Yiyun Wang, Mario A Gomez-Salazar, Ginny Ching-Yun Hsu, Stefano Negri, Zhao Li, Winters Hardy, Lijun Ding, Bruno Peault, Aaron W James

Open access · bronzeAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jiajia XuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-6084-2029
Yiyun WangDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-0775-4377
Mario A Gomez-SalazarDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Ginny Ching-Yun HsuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-5923-3413
Stefano NegriDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Zhao LiDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Winters HardyUCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, California, USA.
Lijun DingCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.ORCID 0000-0002-6330-7945
Bruno PeaultUCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, California, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-2002-622X
Johns Hopkins University · USOrthopaedic Hospital · USNanjing Drum Tower Hospital · CN

Funding

Impact of peripheral nerves on mesenchymal cell fate in extremity traumaR01AR079171 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JAMES, AARON W, LEVI, BENJAMIN · 2021 to 2024
$3.0M
Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
Chief Scientist Office CGA/18/33Medical Research Council G1000816NIAMS NIH HHS R01 AR070773NIAMS NIH HHS R01 AR079171NIDCR NIH HHS R21 DE027922
6 · The paper itself

Abstract

Mesenchymal progenitor cells are broadly distributed across perivascular niches-an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, aldehyde dehydrogenase isoforms, and CD140a, among others. Purified adventicytes (such as CD10

Indexed as

Mesenchymal Stem CellsPericytesAnimalsCell DifferentiationMammalsOsteogenesisTissue EngineeringWound Healingadipogenesisadipose stem cellALDHCD10CD107aCD140aexocytosisLAMP1mesenchymal stem cellmesenchymal stromal cellosteogenesisperivascular stem celltunica adventitia

Identifiers

PMID34252260
PMCPMC8830593
OpenAlexW3177607121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.