Evidence map›Paper›PMID 34252195›Full record

ArticleThe Journal of physiology2021

Interactions of cone cannabinoid CB1 and dopamine D4 receptors increase day/night difference in rod-cone gap junction coupling in goldfish retina.

Jiexin Cao, Stuart C Mangel

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jiexin CaoDivision of Pharmaceutics and Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, USA.
Stuart C MangelDivision of Pharmaceutics and Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, USA.ORCID 0000-0001-5729-1660
The Ohio State University · US

Funding

Neural Circuit Plasticity in the RetinaR01EY029777 · NEI · OHIO STATE UNIVERSITY · PI MANGEL, STUART C · 2019 to 2022
$1.5M
NEI NIH HHS R01 EY029777NIH HHS EY029777
6 · The paper itself

Abstract

key pointsAlthough cone and rod photoreceptor cells in the retina have a type of cannabinoid receptor called a CB1 receptor, little is known about how cannabinoids, the active component in marijuana, affect retinal function. Studies have shown that a circadian (24-h) clock in the retina uses dopamine receptors, which are also on photoreceptors, to regulate gap junctions (a type of cell-to-cell communication) between rods and cones, so that they are functional (open) at night but closed in the day. We show that CB ABSTRACT: Cannabinoid CB

Indexed as

CannabinoidsGoldfishAnimalsGap JunctionsReceptors, Dopamine D4RetinaRetinal Cone Photoreceptor CellsCannabinoidsReceptors, Dopamine D4cannabinoid CB1 receptorcircadian rhythmcone photoreceptor celldopamine D4 receptorelectrical synapsegap junctionrod photoreceptor cell

Identifiers

PMID34252195
PMCPMC8882046
OpenAlexW3179367424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.