ArticleThe journal of trauma and acute care surgery2022
The interaction between pre-admission β-blocker therapy, the Revised Cardiac Risk Index, and mortality in geriatric hip fracture patients.
Article in The journal of trauma and acute care surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 16 citations in OpenAlex.
- Risk factors for and prognosis of postoperative cardiac events in older patients with hip fractures: a retrospective cohort study.Journal of orthopaedic surgery and research · 2025Article
- Morbidity prediction in conservatively managed rib fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Comparison of clinical characteristics and outcomes among different age groups in elderly patients with hip fracture surgery.PloS one · 2025Article
- Cardiac risk stratification and adverse outcomes in surgically managed patients with isolated traumatic spine injuries.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- The mortality burden of frailty in hip fracture patients: a nationwide retrospective study of cause-specific mortality.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Mortality risk stratification in isolated severe traumatic brain injury using the revised cardiac risk index.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Dementia is a surrogate for frailty in hip fracture mortality prediction.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Mode of anesthesia is not associated with outcomes following emergency hip fracture surgery: a population-level cohort study.Trauma surgery & acute care open · 2022Article
- Predicting 1-Year Mortality after Hip Fracture Surgery: An Evaluation of Multiple Machine Learning Approaches.Journal of personalized medicine · 2021Article
- Admission Resting Heart Rate as an Independent Predictor of All-Cause Mortality in Elderly Patients with Hip Fracture.International journal of general medicine · 2021Article
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7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between β-blocker (BB) therapy and a reduced risk of major cardiac events and mortality in patients undergoing surgery for hip fractures has previously been demonstrated. Furthermore, a relationship between an increased Revised Cardiac Risk Index (RCRI) score and a higher risk of postoperative mortality has also been detected. The purpose of the current study was to investigate the interaction between BB therapy and RCRI in relation to 30-day postoperative mortality in geriatric patients after hip fracture surgery.
methodsAll patients older than 65 years who underwent primary emergency hip fracture surgery in Sweden between January 1, 2008, and December 31, 2017, except for pathological fractures, were included in this retrospective cohort study. Patients were divided into cohorts based on their RCRI score (RCRI 1, 2, 3, and ≥4) and whether they had ongoing BB therapy at the time of admission. A Poisson regression model with robust standard errors of variance was used, while adjusting for confounders, to evaluate the association between BB therapy, RCRI, and 30-day mortality.
resultsA total of 126,934 cases met the study inclusion criteria. β-Blocker therapy was associated with a 65% decrease in the risk of 30-day postoperative mortality in the whole study population (adjusted incidence rate ratio [95% confidence interval], 0.35 [0.32-0.38]; p < 0.001). The use of BB also resulted in a significant reduction in 30-day postoperative mortality within all RCRI cohorts. However, the most pronounced effect of BB therapy was seen in patients with an RCRI score greater than 0.
conclusionβ-Blocker therapy is associated with a reduction in 30-day postoperative mortality, irrespective of RCRI score. Furthermore, patients with an elevated cardiac risk appear to have a greater benefit of BB therapy. LEVEL OF EVIDENCE: Therapeutic/care management, level II.
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