Evidence map›Paper›PMID 34252004›Full record

ArticleVirulence2021

Development and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype.

Irene Rodríguez-Arce, Xabier Morales, Mikel Ariz, Begoña Euba, Nahikari López-López, Maider Esparza, Derek W Hood, José Leiva, Carlos Ortíz-de-Solórzano, Junkal Garmendia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Frontiers in cellular and infection microbiology · 2026
    Article
  3. Article
  4. Microbiology spectrum · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Irene Rodríguez-ArceInstituto De Agrobiotecnología, CSIC (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain.
Xabier MoralesDepartment of Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), Laboratory of Preclinical Models and Analytical Tools, Pamplona, Spain.
Mikel ArizDepartment of Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), Laboratory of Preclinical Models and Analytical Tools, Pamplona, Spain.
Begoña EubaInstituto De Agrobiotecnología, CSIC (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain.ORCID 0000-0001-5620-596X
Nahikari López-LópezInstituto De Agrobiotecnología, CSIC (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain.
Maider EsparzaDepartment of Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), Laboratory of Preclinical Models and Analytical Tools, Pamplona, Spain.
Derek W HoodMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK.
José LeivaInstituto De Investigación Sanitaria De Navarra (IdiSNA), Pamplona, Spain.
Carlos Ortíz-de-SolórzanoDepartment of Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), Laboratory of Preclinical Models and Analytical Tools, Pamplona, Spain.
Junkal GarmendiaInstituto De Agrobiotecnología, CSIC (IdAB-CSIC)-Gobierno de Navarra, Mutilva, Spain.ORCID 0000-0002-7440-2737
Gobierno de Navarra · ESNavarre Institute of Health Research · ESCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESMary Lyon Centre at MRC Harwell · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) patients undergo infectious exacerbations whose frequency identifies a clinically meaningful phenotype. Mouse models have been mostly used to separately study both COPD and the infectious processes, but a reliable model of the COPD frequent exacerbator phenotype is still lacking. Accordingly, we first established a model of single bacterial exacerbation by nontypeable

Indexed as

Disease Models, AnimalPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAnimalsDisease ProgressionHaemophilus InfectionsHaemophilus influenzaeHumansMicePancreatic ElastasePhenotypePancreatic Elastasebacterial exacerbationinflammationLung emphysemamicro-CTtest of pulmonary function

Identifiers

PMID34252004
PMCPMC8276669
OpenAlexW3181980175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.