Evidence map›Paper›PMID 34251866›Full record

ArticleJournal of bacteriology2021

A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in

Amanda N D Adams, Muhammad S Azam, Zachary A Costliow, Xiangqian Ma, Patrick H Degnan, Carin K Vanderpool

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. What makes a small RNA work?Nucleic acids research · 2025
    Review
  8. Article
  9. Article
  10. TheFrontiers in cellular and infection microbiology · 2025
    Article
  11. Article
  12. Determinants of raffinose family oligosaccharide use inbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Toward Understanding the Alginate Catabolism inFrontiers in bioengineering and biotechnology · 2022
    Article
  15. Small RNAs Go Global in Human GutJournal of bacteriology · 2021
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amanda N D AdamsDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0003-2688-1849
Muhammad S AzamDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Zachary A CostliowDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Xiangqian MaDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Patrick H DegnanDepartment of Microbiology and Plant Pathology, University of California-Riverside, Riverside, California, USA.
Carin K VanderpoolDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
University of Illinois Urbana-Champaign · USUniversity of California, Riverside · US

Funding

Molecular Determinants of Regulatory Hierarchy for Bacterial Small RNAsR01GM092830 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VANDERPOOL, CARIN K · 2010 to 2020
$2.8M
Small RNA Regulation in BacteriaR35GM139557 · NIGMS · UNIVERSITY OF MINNESOTA · PI Carin K Vanderpool · 2021 to 2026
$2.6M
NIGMS NIH HHS R01 GM092830NIGMS NIH HHS R35 GM139557
6 · The paper itself

Abstract

Human gut microbiome composition is constantly changing, and diet is a major driver of these changes. Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted. Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in

Indexed as

Bacterial ProteinsBacteroides thetaiotaomicronGene Expression Regulation, BacterialHumansPolysaccharides, BacterialRNA-Binding ProteinsBacterial ProteinsPolysaccharides, BacterialRNA-Binding Proteinscapsular polysaccharideCPSHfqmelibiosePULRNA-binding proteinRRM-1

Identifiers

PMID34251866
PMCPMC8508124
OpenAlexW3179271255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.