Evidence map›Paper›PMID 34251726›Full record

ArticleEuropean journal of neurology2021

T cell composition and polygenic multiple sclerosis risk: A population-based study in children.

Casper L de Mol, Kirsten I M Looman, Marvin M van Luijn, Karim L Kreft, Philip R Jansen, Menno C van Zelm, Joost J F M Smolders, Tonya J H White, Henriette A Moll, Rinze F Neuteboom

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Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Casper L de MolDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-3733-1706
Kirsten I M LoomanGeneration R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.
Marvin M van LuijnDepartment of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Karim L KreftDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, the Netherlands.
Philip R JansenGeneration R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.
Menno C van ZelmDepartment of Immunology and Pathology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Victoria, Australia.
Joost J F M SmoldersDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-9766-8661
Tonya J H WhiteDepartment of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands.
Henriette A MollGeneration R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.
Rinze F NeuteboomDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePatients with multiple sclerosis (MS) have altered T cell function and composition. Common genetic risk variants for MS affect proteins that function in the immune system. It is currently unclear to what extent T cell composition is affected by genetic risk factors for MS, and how this may precede a possible disease onset. Here, we aim to assess whether an MS polygenic risk score (PRS) is associated with an altered T cell composition in a large cohort of children from the general population.

methodsWe included genotyped participants from the population-based Generation R study in whom immunophenotyping of blood T cells was performed at the age of 6 years. Analyses of variance were used to determine the impact of MS-PRSs on total T cell numbers (n = 1261), CD4

resultsThe MS-PRS negatively correlated with CD8

conclusionsOur results suggest that MS-associated genetic variants affect T cell composition during childhood in the general population.

Indexed as

Multiple SclerosisChildGenotypeHLA-DRB1 ChainsHumansT-LymphocytesHLA-DRB1 ChainsEpstein-Barr virus infectionsgenetic association studiesmultiple sclerosisT lymphocytesvitamin D

Identifiers

PMID34251726
PMCPMC8596816

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.