ArticleAdvances in experimental medicine and biology2021
Arginine, Agmatine, and Polyamines: Key Regulators of Conceptus Development in Mammals.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Differential Expression and Function of Arginase in Mouse Uterus During Early Pregnancy.International journal of molecular sciences · 2026Article
- Molecular characteristics of follicular fluid in advanced maternal age women with different ovarian reserves: a multi-omics study.BMC women's health · 2026Article
- Metabolomic Markers Reveal How hCG-Ketoprofen Intervention Increase Pregnancy Percentage Following Timed Artificial Insemination in Dairy Cows.Animals : an open access journal from MDPI · 2026Article
- Differences in the Gut Microbiota in Long-Term Infertile Holstein Repeat Breeder Cows and Healthy Fertile Holstein Cows.Animals : an open access journal from MDPI · 2025Article
- The role of ASS1 in mouse embryonic stem cell differentiation into mesendoderm lineages.Stem cell research & therapy · 2025Article
- Agmatine Mitigates Diabetes-Related Memory Loss in Female Mice by Targeting IAntioxidants (Basel, Switzerland) · 2025Article
- Utero-placental adaptations in response to intrauterine growth restriction in swine.Domestic animal endocrinology · 2025Review
- Exogenous progesterone supplementation: a strategy to enhance conceptus development in sheep and pigs?Reproduction & fertility · 2025Review
- The central role of creatine and polyamines in fetal growth restriction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Gut microbiota and metabolic changes in children with idiopathic short stature.BMC pediatrics · 2024Article
- Effects of MnTBAP on Porcine Semen Cryopreservation and Capacitation.Antioxidants (Basel, Switzerland) · 2024Article
- Polyploidy and mTOR signaling: a possible molecular link.Cell communication and signaling : CCS · 2024Review
- Effects ofFoods (Basel, Switzerland) · 2022Article
- LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells.BMC cancer · 2022Article
- Article
- Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health.Advances in experimental medicine and biology · 2022Article
- Functional Molecules of Intestinal Mucosal Products and Peptones in Animal Nutrition and Health.Advances in experimental medicine and biology · 2022Article
- Article
- Editorial: Veterinary Reproductive Immunology.Frontiers in veterinary science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arginine is a key amino acid in pregnant females as it is the precursor for nitric oxide (NO) via nitric oxide synthase and for polyamines (putrescine, spermidine, and spermine) by either arginase II and ornithine decarboxylase to putrescine or via arginine decarboxylase to agmatine and agmatine to putrescine via agmatinase. Polyamines are critical for placental growth and vascularization. Polyamines stabilize DNA and mRNA for gene transcription and mRNA translation, stimulate proliferation of trophectoderm, and formation of multinucleated trophectoderm cells that give rise to giant cells in the placentae of species such as mice. Polyamines activate MTOR cell signaling to stimulate protein synthesis and they are important for motility through modification of beta-catenin phosphorylation, integrin signaling via focal adhesion kinases, cytoskeletal organization, and invasiveness or superficial implantation of blastocysts. Physiological levels of arginine, agmatine, and polyamines are critical to the secretion of interferon tau for pregnancy recognition in ruminants. Arginine, polyamines, and agmatine are very abundant in fetal fluids, fetal blood, and tissues of the conceptus during gestation. The polyamines are thus available to influence a multitude of events including activation of development of blastocysts, implantation, placentation, fetal growth, and development required for the successful establishment and maintenance of pregnancy in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.