ArticleAdvances in experimental medicine and biology2021
Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- A multi-omics systems toxicology framework reveals amino acid-mediated stress adaptation to deltamethrin exposure in a yeast model.Scientific reports · 2026Article
- Plasma amino acid concentrations at admission and 28-day mortality in ST-elevation myocardial infarction.Nutrition & metabolism · 2026Article
- GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential.Journal of translational medicine · 2025Review
- Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stress.Frontiers in pharmacology · 2025Article
- A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy.Bioactive materials · 2024Article
- Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health.Advances in experimental medicine and biology · 2022Article
- Antagonistic potential of Trichoderma as a biocontrol agent againstFrontiers in microbiology · 2022Article
- Functional Molecules of Intestinal Mucosal Products and Peptones in Animal Nutrition and Health.Advances in experimental medicine and biology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins are the chains of amino acids linked via peptide bonds. In cells, newly synthesized proteins are modified and folded in the endoplasmic reticulum (ER) and matured to be functional proteins before they are transported to other tissues or organs. In addition to protein synthesis, the ER is also a stress-sensing organelle for diverse biological functions, such as calcium storage, lipid synthesis, and cellular metabolism. Nutrient deprivation, accumulation of reactive oxygen species, and other intracellular insults can activate ER stress and unfolded protein response (UPR) to restore homeostasis. Dysfunction of the ER influences cellular physiology and metabolism, and contributes to the pathogenesis of various diseases. Amino acids are the building blocks for proteins of eukaryotic organisms. Both in vivo and in vitro studies have found that amino acids can function as signaling molecules to regulate gene expression, cell proliferation and apoptosis, immune response, and antioxidant capacity in numerous biological processes. Importantly, several lines of studies have indicated that amino acids regulate the abundances of proteins implicated in UPR and the redox state, therefore restoring the intracellular homeostasis. Amino acids play an important role in regulating ER stress and redox homeostasis in animal cells for their survival, growth, and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.