Evidence map›Paper›PMID 34251610›Full record

ReviewBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021

How microbiological tests reflect bacterial pathogenesis and host adaptation.

Luisella Spiga, Angel G Jimenez, Renato L Santos, Sebastian E Winter

Open access · bronzeAbstract readReview
In one paragraph

Review in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Unlocking the molecular realm: advanced approaches for identifying clinically and environmentally relevant bacteria.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Luisella Spiga *Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4770-7156
Angel G Jimenez *Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-9949-3874
Renato L SantosDepartamento de Clínica E Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-4830-0470
Sebastian E WinterDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Sebastian.Winter@utsouthwestern.edu.ORCID http://orcid.org/0000-0003-1532-9178
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · USUniversidade Federal de Minas Gerais · BR

Funding

Central metabolism of Salmonella in the inflamed gutR01AI118807 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Sebastian E Winter · 2015 to 2026
$5.3M
Lactate metabolism during Salmonella infectionR21AI128151 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI WINTER, SEBASTIAN E · 2017 to 2018
$446k
NIAID NIH HHS R01 AI118807NIAID NIH HHS R21 AI128151
6 · The paper itself

Abstract

Historically, clinical microbiological laboratories have often relied on isolation of pure cultures and phenotypic testing to identify microorganisms. These clinical tests are often based on specific biochemical reactions, growth characteristics, colony morphology, and other physiological aspects. The features used for identification in clinical laboratories are highly conserved and specific for a given group of microbes. We speculate that these features might be the result of evolutionary selection and thus may reflect aspects of the life cycle of the organism and pathogenesis. Indeed, several of the metabolic pathways targeted by diagnostic tests in some cases may represent mechanisms for host colonization or pathogenesis. Examples include, but are not restricted to, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enterica, Shigella spp., and enteroinvasive Escherichia coli (EIEC). Here, we provide an overview of how some common tests reflect molecular mechanisms of bacterial pathogenesis.

Indexed as

Bacterial InfectionsDysentery, BacillaryHost AdaptationBacteriaHumansLaboratories, ClinicalBacteriaBacterial cultureDiagnostic testsMetabolismPathogenesis

Identifiers

PMID34251610
PMCPMC8578236
OpenAlexW3182020092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.