Evidence map›Paper›PMID 34251569›Full record

ArticleBiogerontology2021

Exercise renovates H

Jing-Ying Lin, Tsung-Jung Ho, Bruce Chi-Kang Tsai, Chien-Yi Chiang, Hui-Chuan Kao, Wei-Wen Kuo, Ray-Jade Chen, Vijaya Padma Viswanadha, Chi-Wen Huang, Chih-Yang Huang

Abstract read
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In one paragraph

Article in Biogerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. CSE/HInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Jing-Ying Lin *Department of Medical Imageing and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Tsung-Jung Ho *Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Bruce Chi-Kang TsaiCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.
Chien-Yi ChiangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.
Hui-Chuan KaoDepartment of Public Health, Tzu Chi University, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Ray-Jade ChenDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Vijaya Padma ViswanadhaDepartment of Biotechnology, Bharathiar University, Coimbatore, India.
Chi-Wen HuangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan. cyhuang@mail.cmu.edu.tw.ORCID 0000-0003-2347-0411
Tzu Chi University · TWAsia University · TWBharathiar University · INCentral Taiwan University of Science and Technology · TWChina Medical University · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is a complex biological process that increases the probability of disease and death, which affects the organs of all species. The accumulation of oxidative damage in the brain contributes to a progressive loss of cognitive functions or even declined the energy metabolism. In this study, we tested the effects of exercise training on the apoptosis, survival, and antioxidant signaling pathways in the cerebral cortex of three age groups of male rats; 3, 12, and 18 months. We observed that H

Indexed as

AntioxidantsNF-E2-Related Factor 2AgingAnimalsApoptosisCerebral CortexMaleRatsAntioxidantsNF-E2-Related Factor 2Age-relatedAnti-oxidantApoptosisBrainH2S

Identifiers

PMID34251569
OpenAlexW3182851747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.