Evidence map›Paper›PMID 34251546›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease.

Claudia Carricarte Naranjo, Connie Marras, Naomi P Visanji, David J Cornforth, Lazaro Sanchez-Rodriguez, Birgitt Schüle, Samuel M Goldman, Mario Estévez, Phyllis K Stein, Anthony E Lang and 2 more

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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Heartbeat signature for predicting motor and non-motor involvement among nonparkinsonian LRRK2 G2019S mutation carriers.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Claudia Carricarte NaranjoFacultad de Biología, Universidad de La Habana, Havana, Cuba. carri@fbio.uh.cu.ORCID 0000-0001-8764-3583
Connie MarrasEdmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.
Naomi P VisanjiEdmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.
David J CornforthMember of the National Coalition of Independent Scholars (NCIS), Battleboro, VT, USA.
Lazaro Sanchez-RodriguezDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Birgitt SchüleDepartment of Pathology, Stanford School of Medicine, Stanford, CA, USA.
Samuel M GoldmanDepartment of Neurology, University of California, San Francisco, CA, USA.
Mario EstévezDepartamento de Neurofisiología Clínica, Instituto de Neurología y Neurocirugía, La Habana, Cuba.
Phyllis K SteinSchool of Medicine, Washington University, St. Louis, MO, USA.
Anthony E LangEdmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.
Herbert F JelinekKhalifa University, Abu Dhabi, UAE.
Andrés MachadoFacultad de Biología, Universidad de La Habana, Havana, Cuba.
Toronto Western Hospital · CAUniversity of Havana · CUInstituto de Neurologia Y Neurocirugia · CUKhalifa University of Science and Technology · AENational Coalition of Independent ScholarsStanford Medicine · USUniversity of Calgary · CAUniversity of California, San Francisco · USWashington University in St. Louis · US

Funding

Michael J. Fox Foundation for Parkinson's Research MJFF 6896NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

purposeCardiac autonomic dysfunction in idiopathic Parkinson's disease (PD) manifests as reduced heart rate variability (HRV). In the present study, we explored the deceleration capacity of heart rate (DC) in patients with idiopathic PD, an advanced HRV marker that has proven clinical utility.

methodsStandard and advanced HRV measures derived from 7-min electrocardiograms in 20 idiopathic PD patients and 27 healthy controls were analyzed. HRV measures were compared using regression analysis, controlling for age, sex, and mean heart rate.

resultsSignificantly reduced HRV was found only in the subcohort of PD patients older than 60 years. Low- frequency power and global HRV measures were lower in patients than in controls, but standard beat-to-beat HRV markers (i.e., rMSSD and high-frequency power) were not significantly different between groups. DC was significantly reduced in the subcohort of PD patients older than 60 years compared to controls.

conclusionsDeceleration-related oscillations of HRV were significantly reduced in the older PD patients compared to healthy controls, suggesting that short-term DC may be a sensitive marker of cardiac autonomic dysfunction in PD. DC may be complementary to traditional markers of short-term HRV for the evaluation of autonomic modulation in PD. Further study to examine the association between DC and cardiac adverse events in PD is needed to clarify the clinical relevance of DC in this population.

Indexed as

Parkinson DiseasePrimary DysautonomiasAutonomic Nervous SystemDecelerationHeart RateHumansCardiac autonomic modulationDeceleration capacity of heart rateHeart rate variabilityIdiopathic Parkinson’s disease

Identifiers

PMID34251546
OpenAlexW3181426730

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.