Evidence map›Paper›PMID 34251518›Full record

ArticleEuropean journal of nutrition2022

Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents.

Geereddy Bhanuprakash Reddy, Tattari Shalini, Santu Ghosh, Raghu Pullakhandam, Boiroju Naveen Kumar, Bharati Kulkarni, Avula Laxmaiah, Umesh Kapil, Sila Deb, Rajkumar Hemalatha and 2 more

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Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Review
  7. β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Geereddy Bhanuprakash ReddyNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Tattari ShaliniNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Santu GhoshDepartment of Physiology, St. John's Medical College, Sarjapur Road, Bengaluru, 560034, India.
Raghu PullakhandamNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Boiroju Naveen KumarNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Bharati KulkarniNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Avula LaxmaiahNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Umesh KapilInstitute of Liver and Biliary Sciences, New Delhi, India.
Sila DebMinistry of Health and Family Welfare, Delhi, India.
Rajkumar HemalathaNational Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Anura V KurpadDepartment of Physiology, St. John's Medical College, Sarjapur Road, Bengaluru, 560034, India. a.kurpad@sjri.res.in.
Harshpal S SachdevDepartment of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India. hpssachdev@gmail.com.
Indian Council of Medical Research · INNational Institute of Nutrition · INSt.John's Medical College Hospital · INInstitute of Liver and Biliary Sciences · INMinistry of Health and Family Welfare · INSitaram Bhartia Institute of Science and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are no representative estimates of vitamin A deficiency (VAD) and risk of vitamin A (VA) dietary inadequacy in Indian children and adolescents. To evaluate, from national surveys, the prevalence of VAD measured by serum retinol concentrations (< 0.7 µmol/L or < 20 µg/dL), and the risk of VA dietary inadequacy and excess intake beyond the tolerable upper limit (TUL).

methodsNational and state-level VAD prevalence adjusted for inflammation was estimated in school-age children (5-9 years: 10,298) and adolescents (10-19 years: 9824) from the Comprehensive National Nutrition Survey (CNNS 2016-18). The risk of dietary inadequacy against age-specific average VA requirements, and excess intake against the TUL, was assessed from the National Sample Survey Office (NSSO 2014) data.

resultsSerum retinol concentrations increased with age (5-19 years) in both genders and were significantly lower in school-age children (1.02 µmol/L, CI: 1.01-1.03) compared to adolescents (1.13 µmol/L, CI 1.12-1.15). The inflammation-adjusted prevalence of VAD in school-age children and adolescents was 19.3% (CI 18.8-19.9) and 14.4% (CI 13.9-14.9) respectively, and this was > 20% in seven and four states for children and adolescents, respectively. The prevalence of VAD was significantly higher among children with lower socio-economic status. The risk of dietary VA inadequacy, from the NSSO survey, was 69 and 78% in children and adolescents, respectively. This risk reduced to 6 and 17% with VA fortified oil and milk intake, while the proportion of intakes exceeding the TUL became 6 and 0.5% in children and adolescents, respectively.

conclusionsThe national prevalence of VAD in school-age children and adolescents in India was just less than 20%. The risk of dietary VA deficiency is likely to decline substantially with VA fortified food intake, but a risk of excessive intake also begins to appear; therefore, a careful assessment of the risk of hypervitaminosis A is required at these ages.

Indexed as

Vitamin A DeficiencyAdolescentAdultChildChild, PreschoolDietFemaleHumansMalePrevalenceSchoolsVitamin AYoung AdultVitamin AAdolescentsCNNSIndiaNSSOSchool-age childrenVitamin A deficiency

Identifiers

PMID34251518
OpenAlexW3180642050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.