Evidence map›Paper›PMID 34251503›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

Anxiolytic-like effect of natural product 2-hydroxy-3,4,6-trimethoxyacetophenone isolated from Croton anisodontus in adult zebrafish via serotonergic neuromodulation involvement of the 5-HT system.

Antonio Wlisses da Silva, Maria Kueirislene A Ferreira, Emanuela L Rebouças, Francisco Rogenio S Mendes, Atilano Lucas Dos S Moura, Jane Eire S A de Menezes, Márcia Machado Marinho, Emmanuel Silva Marinho, Hélcio S Santos, Alexandre M R Teixeira

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Antonio Wlisses da SilvaGraduate Program in Biotechnology, Northeast Biotechnology Network, State University of Ceará, Fortaleza, CE, Brazil.
Maria Kueirislene A FerreiraGraduate Program in Natural Sciences, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.
Emanuela L RebouçasGraduate Program in Biotechnology, Northeast Biotechnology Network, State University of Ceará, Fortaleza, CE, Brazil.
Francisco Rogenio S MendesGraduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brasil.
Atilano Lucas Dos S MouraGraduate Program in Natural Sciences, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.
Jane Eire S A de MenezesGraduate Program in Natural Sciences, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.
Márcia Machado MarinhoFaculty of Philosophy Dom Aureliano Matos, State University of Ceará, Limoeiro do Norte, CE, Brazil.
Emmanuel Silva MarinhoFaculty of Philosophy Dom Aureliano Matos, State University of Ceará, Limoeiro do Norte, CE, Brazil.
Hélcio S SantosGraduate Program in Biotechnology, Northeast Biotechnology Network, State University of Ceará, Fortaleza, CE, Brazil.
Alexandre M R TeixeiraGraduate Program in Biotechnology, Northeast Biotechnology Network, State University of Ceará, Fortaleza, CE, Brazil. alexandre.teixeira@urca.br.ORCID https://orcid.org/0000-0001-6786-2076
Universidade Estadual do Ceará · BRUniversidade Regional do Cariri · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzodiazepines are highly effective in combating anxiety; however, they have considerable adverse effects, so it is important to discover new safe anxiolytic agents. This study was designed to investigate the effect of the natural product 2-hydroxy-3,4,6-trimethoxyacetophenone (HTMCX) on anxiety and seizure behavior in adult zebrafish and its possible mechanisms of action. The acute toxicity of 96 h of HTMCX was analyzed, and the open and light/dark field tests (n = 6 animals/group) were used to assess the anxiety behavior of animals treated with HTMCX. In addition, the mechanisms of action were investigated with antagonists of the GABA

Indexed as

CrotonAcetophenonesAnimalsAnti-Anxiety AgentsAnxietyBiological ProductsFemaleMaleMolecular Docking SimulationNeurotransmitter AgentsPentylenetetrazoleReceptors, SerotoninSeizuresSerotoninZebrafish2-hydroxy-3,4,6-trimethoxyacetophenoneAcetophenonesAnti-Anxiety AgentsBiological ProductsNeurotransmitter AgentsPentylenetetrazoleReceptors, SerotoninSerotonin5HTR1/2CAnxietyCrotonZebrafish

Identifiers

PMID34251503
OpenAlexW3136931247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.