Evidence map›Paper›PMID 34251339›Full record

ArticleeLife2021

E2F/Dp inactivation in fat body cells triggers systemic metabolic changes.

Maria Paula Zappia, Ana Guarner, Nadia Kellie-Smith, Alice Rogers, Robert Morris, Brandon Nicolay, Myriam Boukhali, Wilhelm Haas, Nicholas J Dyson, Maxim V Frolov

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. E2F regulation of theProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maria Paula ZappiaUniversity of Illinois at Chicago, Chicago, United States.ORCID 0000-0003-0449-5445
Ana GuarnerMassachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, United States.
Nadia Kellie-SmithUniversity of Illinois at Chicago, Chicago, United States.
Alice RogersUniversity of Illinois at Chicago, Chicago, United States.
Robert MorrisMassachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, United States.
Brandon NicolayMassachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, United States.
Myriam BoukhaliMassachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, United States.
Wilhelm HaasMassachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, United States.
Nicholas J DysonMassachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, United States.
Maxim V FrolovUniversity of Illinois at Chicago, Chicago, United States.ORCID 0000-0003-3953-3739
Harvard University · USUniversity of Illinois Chicago · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Control of cell proliferation and differentiation by the Retinoblastoma tumor suppressor pathwayR35GM131707 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Maxim Frolov · 2019 to 2026
$4.7M
The consequences of RB-lossR01GM117413 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI DYSON, NICHOLAS J · 2016 to 2019
$2.1M
NIGMS NIH HHS R01 GM117413NIGMS NIH HHS R35 GM131707NIH HHS P40 OD018537
6 · The paper itself

Abstract

The E2F transcription factors play a critical role in controlling cell fate. In

Indexed as

AnimalsCarbohydrate MetabolismCell CycleDrosophilaDrosophila ProteinsE2F Transcription FactorsFat BodyGene Expression Regulation, DevelopmentalMetabolomicsMusclesPhenotypeProteomicsTranscription FactorsTranscription, GeneticTrehaloseDrosophila ProteinsE2F Transcription FactorsTranscription FactorsTrehalosecancer biologydevelopmental biologyD. melanogastere2f/rb pathwayproteomesugar metabolismtrehalosetriglycerides

Identifiers

PMID34251339
PMCPMC8298092
OpenAlexW3181749188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.