Evidence map›Paper›PMID 34251291›Full record

ArticleInfection and immunity2021

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A.

D W Arends, W R Miellet, J D Langereis, T H A Ederveen, C E van der Gaast-de Jongh, M van Scherpenzeel, M J Knol, N M van Sorge, D J Lefeber, K Trzciński and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Transcriptomic analysis ofMicrobial genomics · 2025
    Article
  2. Non-invasiveEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Single-Nucleotide Polymorphisms within theInfection and immunity · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

D W ArendsLaboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-2719-6408
W R MielletNational Institute for Public Health and the Environmentgrid.31147.30, Bilthoven, The Netherlands.
J D LangereisLaboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-5317-3202
T H A EderveenCenter for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
C E van der Gaast-de JonghLaboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
M van ScherpenzeelGlycoMScan, Oss, The Netherlands.
M J KnolNational Institute for Public Health and the Environmentgrid.31147.30, Bilthoven, The Netherlands.
N M van SorgeDepartment of Medical Microbiology and Infection Prevention, Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
D J LefeberTranslational Metabolic Laboratory, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.
K TrzcińskiDepartment of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
E A M SandersNational Institute for Public Health and the Environmentgrid.31147.30, Bilthoven, The Netherlands.
H C DorfmuellerDivision of Molecular Microbiology, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
H J BootsmaLaboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
M I de JongeLaboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-2812-5895
Radboud University Nijmegen · NLNational Institute for Public Health and the Environment · NLUniversity Medical Center Utrecht · NLAmsterdam University Medical Centers · NLUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus pneumoniae serotype 19A prevalence has increased after the implementation of the PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch invasive pneumococcal disease patients and asymptomatic carriers obtained in the period from 2004 to 2016. The whole genomes of the 338 pneumococcal isolates in this cohort were sequenced and their capsule (

Indexed as

Polymorphism, Single NucleotideBacterial CapsulesPromoter Regions, GeneticSerotypingStreptococcus pneumoniaecapsule sheddingDutch cohortpolysaccharide capsuleserotype 19AStreptococcus pneumoniaewhole-genome sequencing

Identifiers

PMID34251291
PMCPMC8519296
OpenAlexW3181336932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.