Evidence map›Paper›PMID 34251286›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection.

Ji Young Lee, Reece P Stevens, Mary Kash, Mikhail F Alexeyev, Ronald Balczon, Chun Zhou, Phoibe Renema, Anna Koloteva, Natalya Kozhukhar, Viktoriya Pastukh and 13 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  2. Article
  3. Article
  4. Carbonic Anhydrase IX: Scaring Away the Grim Reaper in Acute Lung Injury?American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Ji Young LeeDepartment of Physiology and Cell Biology, and.ORCID 0000-0002-8005-2446
Reece P StevensDepartment of Physiology and Cell Biology, and.ORCID 0000-0001-9209-9527
Mary KashCollege of Medicine, University of South Alabama, Mobile, Alabama; and.
Mikhail F AlexeyevDepartment of Physiology and Cell Biology, and.ORCID 0000-0002-5942-0099
Ronald BalczonCenter for Lung Biology.ORCID 0000-0001-8263-7221
Chun ZhouDepartment of Physiology and Cell Biology, and.
Phoibe RenemaDepartment of Physiology and Cell Biology, and.ORCID 0000-0003-0230-7068
Anna KolotevaDepartment of Physiology and Cell Biology, and.
Natalya KozhukharDepartment of Physiology and Cell Biology, and.
Viktoriya PastukhDepartment of Physiology and Cell Biology, and.
Meredith S GwinDepartment of Physiology and Cell Biology, and.ORCID 0000-0002-3084-8032
Sarah VothDepartment of Physiology and Cell Biology, and.ORCID 0000-0003-3796-7154
Althea deWeeverDepartment of Physiology and Cell Biology, and.
Brant M WagenerDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0001-7889-1526
Jean-François PittetDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-2196-9289
Yasaman EslaamizaadDepartment of Internal Medicine.
Waqar SiddiquiDepartment of Internal Medicine.
Talha NawazDepartment of Internal Medicine.
Christopher ClarkeDepartment of Internal Medicine.
Brian W FoutyDepartment of Internal Medicine.
Jonathon P AudiaCenter for Lung Biology.
Diego F AlvarezDepartment of Physiology and Cell Biology, and.ORCID 0000-0001-8244-629X
Troy StevensDepartment of Physiology and Cell Biology, and.ORCID 0000-0001-9689-929X
University of South Alabama · USPulmonary and Critical Care Associates · USUniversity of Alabama at Birmingham · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2001 to 2022
$34.6M
Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Nosocomial pneumonias impair cognitive functionR01HL140182 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Mike Lin · 2018 to 2026
$4.9M
Store-operated calcium entry: lung endothelial permeabilityR37HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2010 to 2019
$3.9M
Store Operated Calcium Entry: Lung Endothelial PermeabilityR01HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 1998 to 2009
$3.0M
Mouse models for mitochondrial disorders caused by mutations in mtDNAR01OD010944 · OD · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F., WALLACE, DOUGLAS C · 2012 to 2020
$2.6M
Caspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0M
The Role of Sex Dimorphism in Post-TBI Bacterial PneumoniaR01GM127584 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WAGENER, BRANT M · 2018 to 2022
$1.9M
Lung Endothelial Aß in infectious proteinopathyR01HL148069 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2020 to 2023
$1.5M
Seahorse XFe24 Extracellular Flux AnalyzerS10OD025089 · OD · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F. · 2019 to 2019
$164k
Carbonic anhydrase IX and pulmonary endothelial cell acidosis during infectionK08HL153958 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEE, JI YOUNG · 2021 to 2021
$160k
Cytotoxic Lung Endothelial AmyloidsF31HL147512 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI VOTH, SARAH B. · 2019 to 2020
$38k
NHLBI NIH HHS F31 HL147512NHLBI NIH HHS K08 HL153958NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL060024NHLBI NIH HHS R01 HL118334NHLBI NIH HHS R01 HL140182NHLBI NIH HHS R01 HL148069NHLBI NIH HHS R37 HL060024NHLBI NIH HHS T32 HL076124NIGMS NIH HHS R01 GM127584NIH HHS R01 OD010944NIH HHS S10 OD025089
6 · The paper itself

Abstract

Low tidal volume ventilation protects the lung in mechanically ventilated patients. The impact of the accompanying permissive hypoxemia and hypercapnia on endothelial cell recovery from injury is poorly understood. CA (carbonic anhydrase) IX is expressed in pulmonary microvascular endothelial cells (PMVECs), where it contributes to CO

Indexed as

AnimalsAntigens, NeoplasmCarbonic Anhydrase IXCell HypoxiaEndothelial CellsHumansLungMalePneumonia, BacterialPseudomonas aeruginosaPseudomonas InfectionsRatsRats, Inbred F344Antigens, NeoplasmCA9 protein, humanCa9 protein, ratCarbonic Anhydrase IXacidosisangiopoietin-2hypercapniapneumoniaultrasound

Identifiers

PMID34251286
PMCPMC8641799
OpenAlexW3181078533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.