Evidence map›Paper›PMID 34251165›Full record

ArticleACS chemical biology2021

Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.

Victoria G Klein, Walter M Bray, Hao-Yuan Wang, Quinn Edmondson, Joshua Schwochert, Satoshi Ono, Matthew R Naylor, Alexandra C Turmon, Justin H Faris, Okimasa Okada and 2 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Interaction ofFrontiers in pharmacology · 2024
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Victoria G KleinDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.ORCID 0000-0002-3438-2399
Walter M BrayDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Hao-Yuan WangDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, 94158, United States.
Quinn EdmondsonDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Joshua SchwochertDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Satoshi OnoInnovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa 227-0033, Japan.ORCID 0000-0001-5631-5923
Matthew R NaylorDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Alexandra C TurmonDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Justin H FarisDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Okimasa OkadaInnovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa 227-0033, Japan.
Jack TauntonDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, 94158, United States.ORCID 0000-0002-9627-5898
R Scott LokeyDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.ORCID 0000-0001-9891-1248

Funding

Cyclic peptide permeabilityR01GM131135 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOKEY, ROBERT SCOTT · 2019 to 2022
$1.3M
NCRR: UCSC Integrated Small Molecule Screening FacilityS10RR022455 · NCRR · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOKEY, R SCOTT · 2007 to 2007
$500k
NCRR NIH HHS S10 RR022455NIGMS NIH HHS R01 GM131135
6 · The paper itself

Abstract

Cordyheptapeptide A is a lipophilic cyclic peptide from the prized

Indexed as

Antineoplastic AgentsCell Line, TumorHumansMolecular StructurePeptide Elongation Factor 1Peptides, CyclicProtein BiosynthesisProtein Synthesis InhibitorsSolid-Phase Synthesis TechniquesStructure-Activity RelationshipAntineoplastic Agentscordyheptapeptide APeptide Elongation Factor 1Peptides, CyclicProtein Synthesis Inhibitors

Identifiers

PMID34251165
PMCPMC8545353

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.