ArticlePediatric blood & cancer2021
Leukaemia and lockdown: The delayed infection model of childhood acute lymphoblastic leukaemia and the COVID-19 pandemic.
Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers.Frontiers in public health · 2024Review
- The Impact of COVID-19 on Pediatric Malignancy Diagnosis and Treatment: Never the Same but Lessons Learned.Vaccines · 2023Review
- Leukaemia and lockdown: The delayed infection model of childhood acute lymphoblastic leukaemia and the COVID-19 pandemic.Pediatric blood & cancer · 2021Article
- Risk Factors for Childhood Leukemia: Radiation and Beyond.Frontiers in public health · 2021Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute lymphoblastic leukaemia (ALL) is the most common type of leukaemia diagnosed in children. The prevailing hypothesis regarding pathogenesis of childhood ALL was developed by Greaves, and states that ALL is caused by an abnormal immune response to a common infection. The response arises either due to naivety of the immune system caused by a lack of common childhood infections, or genetic susceptibility due to specific alleles. The former explanation is known as the delayed infection hypothesis. COVID-19 is a new infection that no children in the UK were exposed to prior to 2020. Furthermore, the lockdown measures designed to prevent spread of this virus have also greatly reduced spread of other common infections. It is therefore important to examine the evidence for this hypothesis, and to consider it in the context of the pandemic to determine what effect lockdown measures may have on incidence of ALL in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.