Evidence map›Paper›PMID 34251039›Full record

ArticleEpilepsia2021

Factors associated with long-term outcomes in pediatric refractory status epilepticus.

Marina Gaínza-Lein, Cristina Barcia Aguilar, Juan Piantino, Kevin E Chapman, Iván Sánchez Fernández, Marta Amengual-Gual, Anne Anderson, Brian Appavu, Ravindra Arya, James Nicholas Brenton and 33 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. [Paediatric status epilepticus].Revista de neurologia · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 17 institutions in 4 countries.

Marina Gaínza-LeinDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9175-9458
Cristina Barcia AguilarDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4719-6683
Juan PiantinoDivision of Neurology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
Kevin E ChapmanPhoenix Children's Hospital, Phoenix, Arizona, USA.
Iván Sánchez FernándezDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4313-002X
Marta Amengual-GualDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-6887-3495
Anne AndersonSection of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Brian AppavuDepartment of Pediatrics, University of Arizona College of Medicine and Barrow's Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona, USA.
Ravindra AryaDivision of Pediatric Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0003-0873-9718
James Nicholas BrentonDepartment of Neurology and Pediatrics, University of Virginia Health System, Charlottesville, Virginia, USA.
Jessica L CarpenterCenter for Neuroscience, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Justice ClarkDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Raquel Farias-MoellerDepartment of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0001-8717-7703
William D GaillardCenter for Neuroscience, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.ORCID 0000-0001-5709-0033
Tracy A GlauserDivision of Pediatric Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Joshua L GoldsteinRuth D. & Ken M. Davee Pediatric Neurocritical Care Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Howard P GoodkinDepartment of Neurology and Pediatrics, University of Virginia Health System, Charlottesville, Virginia, USA.
Linda HuhDepartment of Pediatrics, British Columbia Children's Hospital, University of British Columbia, British Columbia, Canada.
Robert KahoudDivision of Pediatric Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Kush KapurDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Yi-Chen LaiSection of Pediatric Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-9450-5506
Tiffani L McDonoughDepartment of Pediatrics, Division of Neurology and Epilepsy, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mohamad A MikatiDivision of Pediatric Neurology, Duke University Medical Center, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-0363-8715
Lindsey A MorganDepartment of Neurology, Division of Child Neurology, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0003-2206-5561
Anuranjita NayakSection of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Edward NovotnyDepartment of Neurology, Division of Child Neurology, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0001-9726-0447
Adam P OstendorfDepartment of Pediatrics, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA.
Eric T PayneDivision of Neurology, Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
Katrina PearisoDivision of Pediatric Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Latania ReeceDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
James RivielloSection of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Kumar SannagowdaraDepartment of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Tristan T SandsDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0001-7285-1195
Theodore SheehanDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8059-9388
Robert C TaskerDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dmitry TchapyjnikovDivision of Pediatric Neurology, Duke University Medical Center, Duke University, Durham, North Carolina, USA.
Alejandra VasquezDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mark S WainwrightDepartment of Neurology, Division of Child Neurology, Seattle Children's Hospital, Seattle, Washington, USA.
Angus WilfongDepartment of Pediatrics, University of Arizona College of Medicine and Barrow's Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona, USA.
Korwyn WilliamsDepartment of Pediatrics, University of Arizona College of Medicine and Barrow's Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona, USA.
Bo ZhangDepartment of Neurology, Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tobias LoddenkemperDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-2074-0674
Pediatric Status Epilepticus Research Group
Boston Children's Hospital · USBaylor College of Medicine · USBarrow Neurological Institute · USCincinnati Children's Hospital Medical Center · USSeattle Children's Hospital · USChildren's Hospital of Wisconsin · USDuke University · USGeorge Washington University Hospital · USNorthwestern University · USUniversity of Virginia Health System · USChildren's Hospital Colorado · USColumbia University Irving Medical Center · USMayo Clinic · USNationwide Children's Hospital · USOregon Health & Science University · USUniversity of British Columbia · CAUniversity of Calgary · CA

Funding

Impact of Initial Therapy and Response on Long Term Outcome in Children with CAEU01NS045911 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI GLAUSER, TRACY A · 2003 to 2013
$31.1M
The Epilepsy Phenome/ Genome Project (EPGP)U01NS053998 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWENSTEIN, DANIEL H · 2007 to 2013
$26.4M
Consequences of Prolonged Febrile Seizures in ChildhoodR01NS043209 · NINDS · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI SHINNAR, SHLOMO · 2003 to 2012
$21.5M
Consequences of Prolonged Febrile Seizures in ChildhoodR37NS043209 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHINNAR, SHLOMO · 2013 to 2019
$11.4M
Instrumenting the Delivery System for a Genomics Research Information CommonsU01TR002623 · NCATS · BOSTON CHILDREN'S HOSPITAL · PI MANDL, KENNETH D. · 2019 to 2024
$8.6M
Diagnostic validity and safety of high-gamma language mapping with intracranial EEGR01NS115929 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ravindra Arya, NATHAN E CRONE · 2020 to 2026
$3.9M
Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites)U24NS107200 · NINDS · UNIVERSITY OF CINCINNATI · PI Brandon Foreman, TRACY A GLAUSER · 2018 to 2026
$3.3M
Imaging the effect of centrotemporal spikes and seizures on language in childrenR01NS065840 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI VANNEST, JENNIFER J. · 2011 to 2015
$2.5M
Cincinnati Neuroscience Clinical Trials Research Center (CinciNEXT)U10NS077311 · NINDS · UNIVERSITY OF CINCINNATI · PI GLAUSER, TRACY A, WOO, DANIEL · 2011 to 2017
$2.1M
Sodium Channel Gene Variation in the Treatment of EpilepsyR01NS062756 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI HOLLAND, KATHERINE D · 2009 to 2013
$1.6M
Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple SclerosisK23NS116225 · NINDS · UNIVERSITY OF VIRGINIA · PI BRENTON, JAMES NICHOLAS · 2021 to 2025
$962k
Multi-Institutional Pediatric Epilepsy Decision SupportR01LM011124 · NLM · CINCINNATI CHILDRENS HOSP MED CTR · PI PESTIAN, JOHN P · 2011 to 2013
$955k
NCATS NIH HHS U01 TR002623NINDS NIH HHS K23 NS116225NINDS NIH HHS R01 NS043209NINDS NIH HHS R01 NS062756NINDS NIH HHS R01 NS065840NINDS NIH HHS R01 NS115929NINDS NIH HHS R37 NS043209NINDS NIH HHS U01 NS045911NINDS NIH HHS U01 NS053998NINDS NIH HHS U10 NS077311NINDS NIH HHS U24 NS107200NLM NIH HHS R01 LM011124
6 · The paper itself

Abstract

objectiveThis study was undertaken to describe long-term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE.

methodsWe performed retrospective analyses of prospectively collected observational data from June 2011 to March 2020 on pediatric patients with RSE. We analyzed clinical outcomes from at least 30 days after RSE and, in a subanalysis, we assessed developmental outcomes and evaluated risk factors in previously normally developed patients.

resultsFollow-up data on outcomes were available in 276 patients (56.5% males). The median (interquartile range [IQR]) follow-up duration was 1.6 (.9-2.7) years. The in-hospital mortality rate was 4% (16/403 patients), and 15 (5.4%) patients had died after hospital discharge. One hundred sixty-six (62.9%) patients had subsequent unprovoked seizures, and 44 (16.9%) patients had a repeated RSE episode. Among 116 patients with normal development before RSE, 42 of 107 (39.3%) patients with available data had new neurological deficits (cognitive, behavioral, or motor). Patients with new deficits had longer median (IQR) electroclinical RSE duration than patients without new deficits (10.3 [2.1-134.5] h vs. 4 [1.6-16] h, p = .011, adjusted odds ratio = 1.003, 95% confidence interval = 1.0008-1.0069, p = .027). The proportion of patients with an unfavorable functional outcome (Glasgow Outcome Scale-Extended score ≥ 4) was 22 of 90 (24.4%), and they were more likely to have received a continuous infusion. SIGNIFICANCE: About one third of patients without prior epilepsy developed recurrent unprovoked seizures after the RSE episode. In previously normally developing patients, 39% presented with new deficits during follow-up, with longer electroclinical RSE duration as a predictor.

Indexed as

Status EpilepticusAnticonvulsantsChildEpilepsy, GeneralizedFemaleHospital MortalityHumansMaleRetrospective StudiesSeizuresAnticonvulsantsclinical neurologyepilepsyoutcome researchpediatricstatus epilepticus

Identifiers

PMID34251039
PMCPMC9291041
OpenAlexW3182093618

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.