ArticleJournal of Alzheimer's disease : JAD2021
Agitation in Dementia: Real-World Impact and Burden on Patients and the Healthcare System.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Assessing professional caregiver burden related to patient agitation in dementia: A systematic review of measurement scales.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Detecting agitation and aggression in persons living with dementia: a systematic review of diagnostic accuracy.BMC geriatrics · 2024Pooled it
- Comparative efficacy and safety of antidepressant therapy for the agitation of dementia: A systematic review and network meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Longitudinal Impact of Agitation and Aggression Symptoms on Societal Costs in Alzheimer's Disease: A Focus on Informal Care and Socioeconomic Disparities.International journal of geriatric psychiatry · 2026Observational
- Agitation in dementia: Evidence-based consensus recommendations.Journal of the Chinese Medical Association : JCMA · 2026Review
- Physicians' perceptions and treatment practices for agitation associated with Alzheimer's dementia vary by specialty in Japan.Scientific reports · 2026Article
- Agitation in individuals with Alzheimer's disease: An assessment of behaviors using the cohen-mansfield agitation inventory in community-dwellers and impact on caregiver experience.Dementia (London, England) · 2026Article
- Identification of the central symptoms of neuropsychiatric symptoms among older adults with mild cognitive impairment: a network analysis.Frontiers in psychiatry · 2026Article
- Identifying central behavioral and psychological symptoms associated with care time in older adults with dementia: a network analysis.Frontiers in public health · 2026Article
- Current evidence of randomized clinical trials on hospice-eligible patients with agitation and dementia: A narrative review.Palliative & supportive care · 2025Review
- Agitation in Alzheimer's disease: From assessment to therapeutics.World journal of psychiatry · 2025Review
- Behavioral symptoms and treatment challenges for patients living with dementia: Hospice clinician and caregiver perspectives.Journal of the American Geriatrics Society · 2025Article
- Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data.Drugs & aging · 2025Article
- Weighted Blankets for Agitation in Hospitalized Patients with Dementia: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Does an Audio Wearable Lead to Agitation Reduction in Dementia: The Memesto AWARD Proof-of-Principle Clinical Research Study.Research square · 2025Article
- Dose-Response Analysis of Nalbuphine for Alleviating Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy in Men: A Retrospective Study.Drug design, development and therapy · 2025Article
- Study protocol for identification of patients with risk of cognitive impairment in advanced pharmaceutical care in a community pharmacy.Frontiers in public health · 2025Article
- Ascertaining Out-of-Pocket Costs of Dementia Care: Feasibility Study of a Web-Based Weekly Survey.JMIR formative research · 2024Article
- Progress in Pharmacologic Management of Neuropsychiatric Syndromes in Neurodegenerative Disorders: A Review.JAMA neurology · 2024Review
- Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt least 90%of patients with dementia experience behavioral or neuropsychiatric symptoms including agitation, psychotic symptoms, apathy, depression, and sleep disturbances. Agitation has been reported to be experienced by 60%of patients with mild cognitive impairment and 76%of patients with Alzheimer's disease.
objectiveWe aimed to assess the impact of agitation in patients with dementia on healthcare resource utilization (HCRU) and healthcare costs.
methodsThis was a retrospective analysis of physician-reported patient data from a point-in-time survey. Patients included were aged≥50 years, with early cognitive impairment or dementia. Agitated and non-agitated patients were compared. Regression analyses assessed the relationship of agitation score (calculated from number/severity of agitation symptoms) with outcomes, with covariates including age and Mini-Mental State Examination score. Sensitivity analyses compared patients with 0 and≥2 agitation symptoms following propensity score matching on the base-case covariates.
resultsData were included for 1,349 patients (agitated, n = 693; non-agitated, n = 656). Based on regression analyses, agitation score was correlated with proportion of patients with professional caregivers (p < 0.01), institutionalized (p < 0.01), hospitalized in a psychiatric ward (p < 0.05), and receiving an antipsychotic/antidepressant (both p < 0.001); number of consultations with a healthcare professional (HCP), psychiatrist, or psycho-geriatrician; number and cost of hospitalizations (p < 0.01); cost of HCP consultations (p < 0.001); and total direct healthcare costs (p < 0.001). Sensitivity analyses generally supported the base-case analysis.
conclusionAgitation in dementia is associated with increased HCRU and healthcare costs. Effective therapies are needed to address agitation in dementia, with the potential to alleviate patient impact, HCRU, and healthcare costs.
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Registered trials
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