ArticleeLife2021
Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A computational model of the mammalian auditory periphery with a closed-loop medial olivocochlear reflex simulating across-channel efferent gain control.The Journal of the Acoustical Society of America · 2026Article
- Modeling auditory enhancement: Efferent control of cochlear gain can explain level dependence and effects of hearing loss.The Journal of the Acoustical Society of America · 2026Article
- GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Lateral olivocochlear neurons modulate cochlear responses to noise exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neural Fluctuation Contrast as a Code for Complex Sounds: The Role and Control of Peripheral Nonlinearities.Hearing research · 2024Review
- Subcortical auditory model including efferent dynamic gain control with inputs from cochlear nucleus and inferior colliculus.The Journal of the Acoustical Society of America · 2023Article
- Neuropeptide Y Signaling Regulates Recurrent Excitation in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.PLoS genetics · 2023Article
- Neuropeptide Y signaling regulates recurrent excitation in the auditory midbrain.bioRxiv : the preprint server for biology · 2023Article
- The nuclei of the lateral lemniscus: unexpected players in the descending auditory pathway.Frontiers in neuroanatomy · 2023Article
- Electrical signaling in cochlear efferents is driven by an intrinsic neuronal oscillator.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Synaptic plasticity of inhibitory synapses onto medial olivocochlear efferent neurons.The Journal of physiology · 2022Article
- The lateral superior olive in the mouse: Two systems of projecting neurons.Frontiers in neural circuits · 2022Article
- Olivocochlear projections contribute to superior intensity coding in cochlear nucleus small cells.The Journal of physiology · 2022Article
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Authors and funding
2 authors.
Funding
Abstract
Activity in each brain region is shaped by the convergence of ascending and descending axonal pathways, and the balance and characteristics of these determine the neural output. The medial olivocochlear (MOC) efferent system is part of a reflex arc that critically controls auditory sensitivity. Multiple central pathways contact MOC neurons, raising the question of how a reflex arc could be engaged by diverse inputs. We examined functional properties of synapses onto brainstem MOC neurons from ascending (ventral cochlear nucleus, VCN) and descending (inferior colliculus, IC) sources in mice using an optogenetic approach. We found that these pathways exhibited opposing forms of short-term plasticity, with the VCN input showing depression and the IC input showing marked facilitation. By using a conductance-clamp approach, we found that combinations of facilitating and depressing inputs enabled firing of MOC neurons over a surprisingly wide dynamic range, suggesting an essential role for descending signaling to a brainstem nucleus.
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