Evidence map›Paper›PMID 34250803›Full record

ArticleJournal of the American Chemical Society2021

Enabling

Chuanqi Wang, He Zhang, Tao Zhang, Xiaoyu Zou, Hui Wang, Julia E Rosenberger, Raghu Vannam, William S Trout, Jonathan B Grimm, Luke D Lavis and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation.Angewandte Chemie (International ed. in English) · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Senolysis Enabled by Senescent Cell-Sensitive Bioorthogonal Tetrazine Ligation.Angewandte Chemie (International ed. in English) · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Chuanqi WangDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
He ZhangDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0003-1165-6702
Tao ZhangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Xiaoyu ZouDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.
Hui WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Julia E RosenbergerDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Raghu VannamDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-6665-8548
William S TroutDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Jonathan B GrimmJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, United States.ORCID 0000-0003-0331-4200
Luke D LavisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, United States.ORCID 0000-0002-0789-6343
Colin ThorpeDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0001-8238-0112
Xinqiao JiaDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-3564-5576
Zibo LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-1063-0298
Joseph M FoxDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-8258-1640
University of Delaware · USUniversity of North Carolina at Chapel Hill · USHoward Hughes Medical Institute · USBiotechnology Institute · US

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
A Hydrogel-Based Cellular Model of the Human Vocal FoldR01DC014461 · NIDCD · UNIVERSITY OF DELAWARE · PI Xinqiao Jia · 2016 to 2026
$6.2M
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal ChemistryR01GM132460 · NIGMS · UNIVERSITY OF DELAWARE · PI JOSEPH M FOX · 2019 to 2026
$4.2M
High Sensitivity NMR Spectrometer with CryoprobeS10OD025185 · OD · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2019 to 2019
$930k
Multimodal PerkinElmer IVIS-SpectrumCT imaging system for a preclinical imaging core facilityS10OD026951 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YUAN, HONG · 2020 to 2020
$590k
Q-Exactive Orbitrap LC-MC/MS SystemS10OD016267 · OD · UNIVERSITY OF DELAWARE · PI JOHNSTON, MURRAY V · 2013 to 2013
$573k
High Performance Digital NMR SpectrometerS10RR026962 · NCRR · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026962NIDCD NIH HHS R01 DC014461NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R01 GM132460NIH HHS S10 OD016267NIH HHS S10 OD025185NIH HHS S10 OD026951
6 · The paper itself

Abstract

Chromophores that absorb in the tissue-penetrant far-red/near-infrared window have long served as photocatalysts to generate singlet oxygen for photodynamic therapy. However, the cytotoxicity and side reactions associated with singlet oxygen sensitization have posed a problem for using long-wavelength photocatalysis to initiate other types of chemical reactions in biological environments. Herein, silicon-Rhodamine compounds (SiRs) are described as photocatalysts for inducing rapid bioorthogonal chemistry using 660 nm light through the oxidation of a dihydrotetrazine to a tetrazine in the presence of

Indexed as

AnimalsCatalysisCyclooctanesFluorescent DyesHumansInfrared RaysMiceMolecular StructurePhotochemical ProcessesRhodaminesSiliconTetrazolesTumor Cells, CulturedCyclooctanesFluorescent DyesRhodaminesSiliconTetrazoles

Identifiers

PMID34250803
PMCPMC8765119
OpenAlexW3182149902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.