ArticleThe Plant journal : for cell and molecular biology2021
Cadaverine regulates biotin synthesis to modulate primary root growth in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Genomic and metabolomic characterization of Acinetobacter calcoaceticus (DT1) and Citrobacter braakii (S10) reveal functional traits for plant stress alleviation and sustainable agriculture.Functional & integrative genomics · 2026Article
- Physiological and Metabolic Responses of Wheat (ACS agricultural science & technology · 2025Article
- Genome-wide association for multiple quantitative traits in forage oat germplasm based on specific length amplified fragment sequencing.Frontiers in plant science · 2025Article
- Alleviation role of exogenous cadaverine on cell cycle, endogenous polyamines amounts and biochemical enzyme changes in barley seedlings under drought stress.Scientific reports · 2023Article
- Article
- Engineering synthetic microbial consortium for cadaverine biosynthesis from glycerol.Biotechnology letters · 2022Article
- Application of Cadaverine to Inhibit Biotin Biosynthesis in Plants.Bio-protocol · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Cadaverine, a polyamine, has been linked to modification of root growth architecture and response to environmental stresses in plants. However, the molecular mechanisms that govern the regulation of root growth by cadaverine are largely unexplored. Here we conducted a forward genetic screen and isolated a mutation, cadaverine hypersensitive 3 (cdh3), which resulted in increased root-growth sensitivity to cadaverine, but not other polyamines. This mutation affects the BIO3-BIO1 biotin biosynthesis gene. Exogenous supply of biotin and a pathway intermediate downstream of BIO1, 7,8-diaminopelargonic acid, suppressed this cadaverine sensitivity phenotype. An in vitro enzyme assay showed cadaverine inhibits the BIO3-BIO1 activity. Furthermore, cadaverine-treated seedlings displayed reduced biotinylation of Biotin Carboxyl Carrier Protein 1 of the acetyl-coenzyme A carboxylase complex involved in de novo fatty acid biosynthesis, resulting in decreased accumulation of triacylglycerides. Taken together, these results revealed an unexpected role of cadaverine in the regulation of biotin biosynthesis, which leads to modulation of primary root growth of plants.
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