ArticleBlood cancer discovery2021
Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.
Open access · greenAbstract read
In one paragraph
Article in Blood cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 142 citations in OpenAlex.
- Trial
- Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults.The New England journal of medicine · 2024Trial
- Combined Early Steroid Response and MRD Improve Risk Stratification in Pediatric Acute Lymphoblastic Leukemia: The CCCG-ALL-2015 Study.European journal of haematology · 2026Article
- Article
- Plasticity under pressure: biology and detection of lineage switch in acute leukemia.Leukemia · 2026Review
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia.Cell reports. Medicine · 2026Article
- Pitfalls and Challenges in the Detection of ZNF384 Rearrangements by Fluorescence in Situ Hybridization.Genes, chromosomes & cancer · 2026Article
- Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts.HemaSphere · 2026Article
- Hyperleukocytosis and outcomes in pediatric B-cell acute lymphoblastic leukemia: A report from the REDIAL Consortium.medRxiv : the preprint server for health sciences · 2026Article
- A novelBlood science (Baltimore, Md.) · 2026Article
- CD33 expression combined with D15-MRD positivity identifies poor prognosis in children with ETV6::RUNX1-positive ALL.Annals of hematology · 2026Article
- Molecular Characterization of T-Lineage Acute Lymphoblastic Leukemia by an Optimal-Transport Based Multi-Omics Integration Framework.bioRxiv : the preprint server for biology · 2026Article
- Artificial intelligence reshaping the paradigm of hematologic malignancy diagnosis and treatment: From static assessment to dynamic precision management.Annals of hematology · 2026Review
- Biological and clinical characteristics ofHemaSphere · 2026Article
- Pseudogene Coexpression Networks Reveal a Robust Prognostic Signature for Pediatric B-ALL Survival.Cancer research communications · 2026Article
- Space-time clustering of childhood high hyperdiploid B-cell precursor acute lymphoblastic leukemia: a nationwide Swedish study.European journal of epidemiology · 2026Article
- RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B-Cell Acute Lymphoblastic Leukemia.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- [Clinical characteristics of DUX4-IGH fusion B-cell acute lymphoblastic leukemia in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
22 authors at 2 institutions in 2 countries.
Sima Jeha *Department of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
John Choi *Department of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Kathryn G Roberts *Department of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0001-7626-4043
Deqing PeiDepartment of Biostatistics, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Elaine Coustan-SmithDepartment of Pediatrics, School of Medicine, National University of Singapore, Singapore.
Hiroto InabaDepartment of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Jeffrey E RubnitzDepartment of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0001-9885-3527
Raul C RibeiroDepartment of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0002-9956-5647
Tanja A GruberDepartment of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Susana C RaimondiDepartment of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Seth E KarolDepartment of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0001-8113-8180
Chunxu QuDepartment of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Samuel W BradyDepartment of Computational Biology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Zhaohui GuDepartment of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0003-1581-1327
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Cheng ChengDepartment of Biostatistics, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Williams E EvansDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Mary V RellingDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee.
Dario CampanaDepartment of Pediatrics, School of Medicine, National University of Singapore, Singapore.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee. ching-hon.pui@stjude.org Charles.mullighan@stjude.org.ORCID 0000-0002-1871-1850
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee. ching-hon.pui@stjude.org Charles.mullighan@stjude.org.ORCID 0000-0003-0303-5658
St. Jude Children's Research Hospital · USNational University of Singapore · SG
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RELLING, MARY V · 2015 to 2019
$15.1MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MPHARMACOGENOMICS OF CHILDHOOD LEUKEMIA (ALL)R37CA036401 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI EVANS, WILLIAM E · 1987 to 2014
$9.7MPharmacogenomics of Childhood Leukemia ALLR01CA036401 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI EVANS, WILLIAM E · 1985 to 2019
$3.6MPathogenesis of ETV6-Related Acute Lymphoblastic LeukemiaR01CA241452 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI NICHOLS, KIM ERIKA · 2020 to 2025
$2.6MARID5B and disparities of childhood leukemiaU01CA176063 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN J. · 2014 to 2018
$2.4MGenetics-guided Individualization of Thiopurine TherapyR01GM118578 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN J. · 2017 to 2020
$2.2MHypertension Intervention to Reduce Osteonecrosis in Children with Acute Lymphoblastic LeukemiaK08CA250418 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KAROL, SETH EVAN · 2020 to 2024
$1.1MNCI NIH HHS K08 CA250418NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA036401NCI NIH HHS R01 CA241452NCI NIH HHS R35 CA197695NCI NIH HHS R37 CA036401NCI NIH HHS U01 CA176063NIGMS NIH HHS P50 GM115279NIGMS NIH HHS R01 GM118578
Abstract
We evaluate clinical significance of recently identified subtypes of acute lymphoblastic leukemia (ALL) in 598 children treated with minimal residual disease (MRD)-directed therapy. Among the 16 B-ALL and 8 T-ALL subtypes identified by next generation sequencing,
Indexed as
Precursor Cell Lymphoblastic Leukemia-LymphomaPrecursor T-Cell Lymphoblastic Leukemia-LymphomaChildChromosome AberrationsHumansNeoplasm, ResidualPrognosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.