ArticleRadiology. Cardiothoracic imaging2021
Accelerated in Vivo Cardiac Diffusion-Tensor MRI Using Residual Deep Learning-based Denoising in Participants with Obesity.
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Article in Radiology. Cardiothoracic imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Voxel-scale diffusion tensor phenomapping of the healthy and pressure-overloaded human heart.Nature biomedical engineering · 2026Article
- Free-Breathing Multi-Slice Co-Registered Cardiac T1, T2, and ADC Mapping With Spin-Echo Echo Planar Imaging.Magnetic resonance in medicine · 2026Article
- Promises and challenges of AI-enabled methods for myocardial characterisation in cardiovascular magnetic resonance.Frontiers in cardiovascular medicine · 2026Review
- Article
- In vivo cardiac diffusion tensor imaging on an MR system featuring ultrahigh performance gradients with 200 mT/m maximum gradient strength.Magnetic resonance in medicine · 2025Article
- Accelerating cardiac diffusion tensor imaging with deep learning-based tensor de-noising and breath hold reduction. A step towards improved efficiency and clinical feasibility.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
- Deep learning-based diffusion tensor cardiac magnetic resonance reconstruction: a comparison study.Scientific reports · 2024Article
- Deep learning denoising reconstruction for improved image quality in fetal cardiac cine MRI.Frontiers in cardiovascular medicine · 2024Article
- Present and Future Innovations in AI and Cardiac MRI.Radiology · 2024Review
- Accelerating Cardiac Diffusion Tensor Imaging With a U-Net Based Model: Toward Single Breath-Hold.Journal of magnetic resonance imaging : JMRI · 2022Article
- Feasibility study of clinical target volume definition for soft-tissue sarcoma using muscle fiber orientations derived from diffusion tensor imaging.Physics in medicine and biology · 2022Article
- AI Denoising Significantly Enhances Image Quality and Diagnostic Confidence in Interventional Cone-Beam Computed Tomography.Tomography (Ann Arbor, Mich.) · 2022Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Kellie PhippsCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0002-1664-6485
Maaike van de BoomenCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0003-2526-6553
Robert EderCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0003-0161-7937
Sam Allen MichelhaughCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0002-7440-584X
Aferdita SpahillariCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0002-9157-5648
Joan KimCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
Shestruma ParajuliCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0003-0043-9673
Timothy G ReeseCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
Choukri MekkaouiCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
Denise GeeCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
Ravi ShahCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
David E SosnovikCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0002-6486-7434
Christopher NguyenCardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.ORCID https://orcid.org/0000-0003-1475-2329
University Medical Center Groningen · NLAthinoula A. Martinos Center for Biomedical Imaging · US
Funding
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4MImaging Histone Deacetylase in the Heart and Bone MarrowR01HL141563 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2018 to 2021
$3.3MMicrostructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2MStress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)R01HL135242 · NHLBI · UNIVERSITY OF UTAH · PI NATARAJAN, PRADEEP · 2017 to 2020
$2.8MFree-Breathing Diffusion Tensor MRI in Patients Following Myocardial InfarctionR01HL131635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI · 2016 to 2020
$2.1MNHLBI NIH HHS R01 HL131635NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL141563NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159010
Abstract
purposeTo develop and assess a residual deep learning algorithm to accelerate in vivo cardiac diffusion-tensor MRI (DT-MRI) by reducing the number of averages while preserving image quality and DT-MRI parameters. MATERIALS AND
methodsIn this prospective study, a denoising convolutional neural network (DnCNN) for DT-MRI was developed; a total of 26 participants, including 20 without obesity (body mass index [BMI] < 30 kg/m
resultsNo differences were found in image quality or DT-MRI parameters between the accelerated 4Av
conclusionCardiac DT-MRI can be performed at an at least twofold-accelerated rate by using DnCNN to preserve image quality and DT-MRI parameter quantification.
Indexed as
AdultsCardiacHeartMR-Diffusion Tensor ImagingObesityTechnology AssessmentTissue Characterization
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