Evidence map›Paper›PMID 34250454›Full record

ReviewACS applied bio materials2021

Peptide-Modified Biopolymers for Biomedical Applications.

Jessica Hersh, David Broyles, José Manuel Condor Capcha, Emre Dikici, Lina A Shehadeh, Sylvia Daunert, Sapna Deo

Open access · greenAbstract readReview
In one paragraph

Review in ACS applied bio materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

  1. Validation ofACS central science · 2026
    Article
  2. Review
  3. Polymeric Nanoparticles for Wound Healing.Pharmaceutical nanotechnology · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jessica HershDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.ORCID 0000-0003-0875-4248
David BroylesDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.
José Manuel Condor CapchaInterdisciplinary Stem Cell Institute and Division of Cardiology, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.
Emre DikiciDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.
Lina A ShehadehInterdisciplinary Stem Cell Institute and Division of Cardiology, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.
Sylvia DaunertDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.ORCID 0000-0003-4760-5528
Sapna DeoDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, United States.ORCID 0000-0002-4926-5355
University of Miami · US

Funding

Targeted cell delivery for treatment of non-healing wounds and gangreneR01HL149452 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DAUNERT, SYLVIA, LIU, ZHAO-JUN · 2019 to 2022
$2.8M
Sensitive Detection of Viral Persistency Using Bioluminescent Stem-Loop ProbesR01GM114321 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DEO, SAPNA K · 2015 to 2019
$1.5M
Portable, Rapid, Multiplexed Flow strip Test for BacteriaR01GM127706 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DAUNERT, SYLVIA, DEO, SAPNA K · 2018 to 2021
$1.2M
NHLBI NIH HHS R01 HL149452NIGMS NIH HHS R01 GM114321NIGMS NIH HHS R01 GM127706
6 · The paper itself

Abstract

Polymeric biomaterials have been used in a variety of applications, like cargo delivery and tissue scaffolding, because they are easily synthesized and can be adapted to many systems. However, there is still a need to further enhance and improve their functions to progress their use in the biomedical field. A promising solution is to modify the polymer surfaces with peptides that can increase biocompatibility, cellular interactions, and receptor targeting. In recent years, peptide modifications have been used to overcome many challenges to polymer biomaterial development. This review discusses recent progress in developing peptide-modified polymers for therapeutic applications including cell-specific targeting and tissue engineering. Furthermore, we will explore some of the most frequently studied base components of these biomaterials.

Indexed as

AnimalsAntigen-Presenting CellsBiopolymersBrainBrain NeoplasmsHumansNanoparticlesPeptidesTissue EngineeringTissue ScaffoldsBiopolymersPeptidespeptide modificationspolymeric therapeuticspolymerstargetingtissue engineering

Identifiers

PMID34250454
PMCPMC8267604
OpenAlexW3116614979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.