Evidence map›Paper›PMID 34250407›Full record

ArticleJCO precision oncology2021

Interplay Between Class II HLA Genotypes and the Microbiome and Immune Phenotypes in Individuals With PTEN Hamartoma Tumor Syndrome.

Margaret Jia, Naseer Sangwan, Alice Tzeng, Charis Eng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Margaret JiaGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH.
Naseer SangwanCenter for Microbiome in Health and Disease, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Alice TzengGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH.
Charis EngGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Selective Modulation of Thyroidal RadioiodineP01CA124570 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2008 to 2017
$23.4M
Toward better characterization and clinical trial readiness for targeting neuropsychiatric manifestations in PTEN pathogenic variantsU54NS092090 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI M. Pilar Trelles · 2014 to 2026
$20.1M
NCI NIH HHS P01 CA124570NINDS NIH HHS U54 NS092090
6 · The paper itself

Abstract

We evaluate potential contributors to the development of autoimmunity and other phenotypes consistent with immune dysregulation in individuals with germline mutations in the tumor suppressor gene MATERIALS AND

methodsIllumina sequencing of bacterial and fungal microbes was carried out on patient-donated fecal samples in a cohort of 67 patients with pathogenic germline

resultsWe found that alpha diversity distributions for both bacterial and fungal genera were statistically different between cases and controls. We identified differentially abundant bacterial and fungal taxa between cases and controls. Network analysis of differentially abundant bacterial taxa revealed some co-varying bacterial genera. We additionally found significant correlations between certain HLA genotypes and certain taxa and significant correlations between HLA diversity and alpha diversity.

conclusion

Indexed as

AdolescentAdultAgedChildChild, PreschoolFemaleGenotypeHamartoma Syndrome, MultipleHistocompatibility Antigens Class IIHumansMaleMicrobiotaMiddle AgedPhenotypeYoung AdultHistocompatibility Antigens Class II

Identifiers

PMID34250407
PMCPMC8232567
OpenAlexW3126243107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.