ArticleJCO precision oncology2021
Prevalence and Characterization of Biallelic and Monoallelic
Open access · greenAbstract read
In one paragraph
Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Molecular Basis of Adenomatous Gastrointestinal Polyposis Syndromes: Role of Pathogenic and Benign Variants in Disease Onset.Biomedicines · 2026Article
- Tumour spectrum, distinguishing features and management recommendations for NTHL1-associated tumour syndrome: a systematic review.Hereditary cancer in clinical practice · 2025Review
- Whole-exome sequencing identifies new pathogenic germline variants in patients with colorectal polyposis.World journal of gastroenterology · 2025Article
- Genetics, genomics and clinical features of adenomatous polyposis.Familial cancer · 2025Review
- Prevalence of germline variants in Brazilian pancreatic carcinoma patients.Scientific reports · 2024Article
- Founder pathogenic variants in colorectal neoplasia susceptibility genes in Ashkenazi Jews undergoing colonoscopy.BJC reports · 2024Article
- NTHL1 is a recessive cancer susceptibility gene.Scientific reports · 2023Article
- Genetic Predisposition to Colorectal Cancer: How Many and Which Genes to Test?International journal of molecular sciences · 2023Review
- Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in whichFrontiers in immunology · 2023Article
- Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases.Frontiers in oncology · 2023Article
- Article
- How many is too many? Polyposis syndromes and what to do next.Current opinion in gastroenterology · 2022Review
- Novel Genetic Causes of Gastrointestinal Polyposis Syndromes.The application of clinical genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 1 institution in 1 country.
Erin E Salo-MullenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Anna MaioDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Semanti MukherjeeDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-1843-9359
Chaitanya BandlamudiMarie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Jinru ShiaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-4351-2511
Yelena KemelDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-5042-5651
Karen A CadooDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-8384-7148
Ying LiuDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5790-851X
Maria CarloDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-4786-7408
Megha RanganathanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-3245-8812
Sarah KaneDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Preethi SrinivasanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Shweta S ChavanMarie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-9433-6936
Mark T A DonoghueMarie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Caitlin BourqueMarie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Margaret SheehanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Prince Rainier TejadaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Zalak PatelDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Angela G ArnoldDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Jennifer A KennedyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Kimberly AmorosoDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-2884-7962
Kelsey BreenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-7302-1564
Amanda CatchingsDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-6005-4778
Rosalba SaccaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Vanessa MarcellDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Arnold J MarkowitzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-5449-9623
Alicia LathamDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9758-713X
Michael WalshDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5006-6778
Maksym MisyuraDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Ozge Ceyhan-BirsoyDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
David B SolitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-6614-802X
Michael F BergerMarie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-3882-5000
Mark E RobsonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-3109-1692
Barry S TaylorMarie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-3355-9471
Kenneth OffitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-2180-2032
Diana MandelkerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Zsofia K StadlerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-6985-2864
Memorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MSPORE in Bladder CancerP50CA221745 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BAJORIN, DEAN F. · 2018 to 2024
$11.8MNCI NIH HHS P30 CA008748NCI NIH HHS P50 CA221745
Abstract
MATERIALS AND
methodsPatients with pan-cancer (n = 11,081) underwent matched tumor-normal sequencing with consent for germline analysis. Medical records and tumors were reviewed and analyzed. Prevalence of PVs was compared with reference controls (Genome Aggregation Database).
results
conclusion
Indexed as
HeterozygoteAdolescentAdultAgedAllelesChildChild, PreschoolColonic PolypsColorectal NeoplasmsDeoxyribonuclease (Pyrimidine Dimer)FemaleGenetic VariationHumansInfantMaleMiddle AgedDeoxyribonuclease (Pyrimidine Dimer)MSH3 protein, humanMutS Homolog 3 ProteinNTHL1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.