Evidence map›Paper›PMID 34250319›Full record

ArticleKidney international reports2021

Review of Early Immune Response to SARS-CoV-2 Vaccination Among Patients With CKD.

Edward J Carr, Andreas Kronbichler, Matthew Graham-Brown, Graham Abra, Christos Argyropoulos, Lorraine Harper, Edgar V Lerma, Rita S Suri, Joel Topf, Michelle Willicombe and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05057936 (Antibody Response After COVID-19 Vaccination in Chronic Kidney Disease and Kidney Transplant Patients), which is not on this map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05057936 completednot on this map

Antibody Response After COVID-19 Vaccination in Chronic Kidney Disease and Kidney Transplant Patients

TypeobservationalSponsorBangkok Metropolitan Administration Medical College and Vajira HospitalRan2021 to 2021Enrolled140ConditionsCovid19, Breakthrough Infection, CKD, Kidney TransplantArmsCOVID vaccine
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Article
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  8. Article
  9. Review
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  11. Article
  12. Article
  13. Vaccinated kidney transplant recipients are yet not sufficiently protected against COVID-19.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  14. Oral antiviral therapies for COVID-19 in patients with advanced chronic kidney disease or kidney failure.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 3 countries.

Edward J CarrThe Francis Crick Institute, London, UK.
Andreas KronbichlerDepartment of Medicine, University of Cambridge, Cambridge, UK.
Matthew Graham-BrownDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Graham AbraSatellite Healthcare, San Jose, California, USA.
Christos ArgyropoulosDivision of Nephrology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Lorraine HarperInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Edgar V LermaSection of Nephrology, University of Illinois at Chicago/Advocate Christ Medical Center, Oak Lawn, Illinois, USA.
Rita S SuriResearch Institute, University Health Center, Department of Medicine, McGill University, Montreal, Québec, Canada.
Joel TopfDepartment of Medicine, Oakland University William Beaumont School of Medicine, Detroit, Michigan, USA.
Michelle WillicombeDepartment of Inflammation and Immunity, Imperial College, London, UK.
Swapnil HiremathDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Imperial College London · GBMcGill University Health Centre · CAOakland University · USSatellite Healthcare (United States) · USThe Francis Crick Institute · GBUniversity of Birmingham · GBUniversity of Cambridge · GBUniversity of Illinois Chicago · USUniversity of Leicester · GBUniversity of New Mexico · USUniversity of Ottawa · CA

Funding

Medical Research Council MR/W010011/1
6 · The paper itself

Abstract

The effects of the coronavirus disease-2019 (COVID-19) pandemic, particularly among those with chronic kidney disease (CKD), who commonly have defects in humoral and cellular immunity, and the efficacy of vaccinations against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are uncertain. To inform public health and clinical practice, we synthesized published studies and preprints evaluating surrogate measures of immunity after SARS-CoV-2 vaccination in patients with CKD, including those receiving dialysis or with a kidney transplant. We found 35 studies (28 published, 7 preprints), with sample sizes ranging from 23 to 1140 participants and follow-up ranging from 1 week to 1 month after vaccination. Seventeen of these studies enrolled a control group. In the 22 studies of patients receiving dialysis, the development of antibodies was observed in 18% to 53% after 1 dose and in 70% to 96% after 2 doses of mRNA vaccine. In the 14 studies of transplant recipients, 3% to 59% mounted detectable humoral or cellular responses after 2 doses of mRNA vaccine. After vaccination, there were a few reported cases of relapse or

Indexed as

coronavirusCOVIDCOVID-19dialysiskidney diseasetransplantvaccine

Identifiers

PMID34250319
PMCPMC8257418
OpenAlexW3177852708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.