ArticleJournal of veterinary research2021
Evaluation of Serum and Urine Neutrophil Gelatinase-associated Lipocalin and Cystatin C as Biomarkers of Acute Kidney Injury in Horses.
Article in Journal of veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- Neutrophil Gelatinase-Associated Lipocalin in Synovial Fluid from Horses with and without Septic Arthritis.Animals : an open access journal from MDPI · 2022Article
- Biomarkers of Kidney Disease in Horses: A Review of the Current Literature.Animals : an open access journal from MDPI · 2022Review
- ECEIM consensus statement on equine kidney disease.Journal of veterinary internal medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiagnosis of acute kidney injury (AKI) in horses is difficult at the subclinical stage, due to nonspecific clinical signs. The aim of this study was to evaluate the concentrations of selected serum and urinary biomarkers in healthy horses, horses at risk of AKI, and those with clinical AKI. MATERIAL AND
methodsThirty healthy horses, 30 horses at risk of AKI and 11 horses with clinical AKI and azotaemia were included in the study. Serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C were measured using commercially available enzyme immunoassay tests.
resultsThe median and (in parentheses) first and third quartile concentrations of selected biomarkers in healthy horses, horses at risk of AKI and horses with AKI were respectively as follows: serum cystatin C - 0.25 (0.19-0.37), 0.23 (0.15-0.37) and 0.61 (0.37-1.13) mg/L; serum NGAL - 50.5 (38.8-58.8), 51.1 (40.4-66.9) and 98.1 (59.4-128.2) ng/mL; urinary NGAL - 20.7 (17.9-24.5), 32.3 (32.7-55.8) and 36.6 (26.8-89.9) ng/mL; and urinary cystatin C - 0.1 (0.07-0.13), 0.13 (0.1-0.2) and 0.34 (0.22-0.37) mg/L. There were significant differences in the concentration of all biomarkers between the healthy and AKI-affected horses.
conclusionHorses with AKI all had biomarker concentrations higher than the healthy horses. None of the biomarkers made azotaemia recognisable in all affected horses. The obtained results indicate the need to create a serum and urinary biomarker panel to detect AKI.
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