Evidence map›Paper›PMID 34250187›Full record

ArticleOpen forum infectious diseases2021

Poppers, by Inducing HHV-8 Virion Production, Can Act as a Promoter for HHV-8 Transmission in Men Who Have Sex With Men.

Aude Jary, Adélie Gothland, Romain Palich, Valentin Leducq, Gentiane Monsel, Sébastien Imbert, Luminita Schneider, Anne Simon, Jean-Philippe Spano, Christine Katlama and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Aude JarySorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Virology, Paris, France.
Adélie GothlandSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Virology, Paris, France.
Romain PalichSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Infectious Diseases, Paris, France.ORCID https://orcid.org/0000-0003-0047-0101
Valentin LeducqSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Virology, Paris, France.
Gentiane MonselSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Infectious Diseases, Paris, France.
Sébastien ImbertAssistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Parasitology-Mycology, Paris, France.
Luminita SchneiderSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Infectious Diseases, Paris, France.
Anne SimonAssistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Internal Medicine, Paris, France.
Jean-Philippe SpanoSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Oncology, Paris, France.
Christine KatlamaSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Infectious Diseases, Paris, France.
Islam Amine LarabiParis-Saclay University, Institut National de la Santé et de la Recherche Médicale U-1173, Department of Pharmacology Toxicology, Assistance Publique - Hôpitaux de Paris, Raymond Poincaré Hospital, Garches, France.
Jean-Claude AlvarezParis-Saclay University, Institut National de la Santé et de la Recherche Médicale U-1173, Department of Pharmacology Toxicology, Assistance Publique - Hôpitaux de Paris, Raymond Poincaré Hospital, Garches, France.
Vincent CalvezSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Virology, Paris, France.
Anne-Geneviève MarcelinSorbonne Université, Institut National de la Santé et de la Recherche Médicale, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière Hospital, Department of Virology, Paris, France.
Inserm · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental factors were reported to increase the risk of human herpesvirus 8 (HHV-8) transmission. In a population of men who have sex with men (MSM), we found evidence that chemsex was associated with human herpesvirus 8 seropositivity in vivo and that poppers induced HHV-8 virion production in vitro. Our finding may explain the higher HHV-8 transmission in MSM.

Indexed as

chemsexHHV-8HHV-8 productionHIV PrEPMSMpoppers

Identifiers

PMID34250187
PMCPMC8266588
OpenAlexW3144865506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.