ArticleOpen forum infectious diseases2021
Understanding Nonadherence to Tuberculosis Medications in India Using Urine Drug Metabolite Testing: A Cohort Study.
Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Barriers to and enablers of adherence to the treatment of active drug-sensitive tuberculosis in people living with HIV: a mixed method systematic review.BMC public health · 2025Pooled it
- Review: missed tuberculosis cases in India: a systematic analysis of diagnostic, treatment, and reporting gaps.BMC health services research · 2025Pooled it
- Health literacy and tuberculosis control: systematic review and meta-analysis.Bulletin of the World Health Organization · 2024Pooled it
- Barriers to engagement in the care cascade for tuberculosis disease in India: A systematic review of quantitative studies.PLoS medicine · 2024Pooled it
- Alternative Methods for Therapeutic Drug Monitoring and Dose Adjustment of Tuberculosis Treatment in Clinical Settings: A Systematic Review.Clinical pharmacokinetics · 2023Pooled it
- Can digital adherence technologies reduce inequity in tuberculosis treatment success? Evidence from a randomised controlled trial.BMJ global health · 2022Trial
- Prescribing skills course: Three years' experience and lessons learnt through India's massive open online course.British journal of clinical pharmacology · 2026Article
- Estimating the effect of hepatitis C infection on multidrug-resistant tuberculosis treatment outcomes under hypothetical interventions on regimen composition and adherence.American journal of epidemiology · 2026Observational
- Measurement of Tuberculosis treatment adherence: A methodological scoping review of observational studies.PLOS global public health · 2026Article
- Integrating narrative and bibliometric approaches to examine factors and impacts of tuberculosis treatment non-compliance.Multidisciplinary respiratory medicine · 2025Article
- Contextual factors influencing implementation of tuberculosis digital adherence technologies: a scoping review guided by the RE-AIM framework.BMJ global health · 2025Article
- Medication nonadherence and associated factors in patients with tuberculosis in Wau, South Sudan: a cross- sectional study using the world health organization multidimensional adherence model.Archives of public health = Archives belges de sante publique · 2024Article
- The Assessment of Serum Fibronectin Levels as a Potential Biomarker for the Severity of Drug-Sensitive Pulmonary Tuberculosis: A Pilot Study.Diagnostics (Basel, Switzerland) · 2023Article
- Factors affecting ability of TB patients to follow treatment guidelines - applying a capability approach.International journal for equity in health · 2023Article
- Assessment of TB treatment adherence using computer-assisted self-interviewing.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Impact of the 99DOTS digital adherence technology on tuberculosis treatment outcomes in North India: a pre-post study.BMC infectious diseases · 2023Article
- Self-reported medication adherence instruments and their applicability in low-middle income countries: a scoping review.Frontiers in public health · 2023Article
- Adherence trajectory as an on-treatment risk indicator among drug-resistant TB patients in the Philippines.PloS one · 2022Article
- Measuring Tuberculosis Medication Adherence: A Comparison of Multiple Approaches in Relation to Urine Isoniazid Metabolite Testing Within a Cohort Study in India.Open forum infectious diseases · 2021Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundPoor adherence to tuberculosis (TB) treatment is associated with disease recurrence and death. Little research has been conducted in India to understand TB medication nonadherence.
methodsWe enrolled adult drug-susceptible TB patients, approximately half of whom were people with human immunodeficiency virus (PWH), in Chennai, Vellore, and Mumbai. We conducted a single unannounced home visit to administer a survey assessing reasons for nonadherence and collect a urine sample that was tested for isoniazid content. We described patient-reported reasons for nonadherence and identified factors associated with nonadherence (ie, negative urine test) using multivariable logistic regression. We also assessed the association between nonadherence and treatment outcomes.
resultsOf 650 participants in the cohort, 77 (11.8%) had a negative urine test. Nonadherence was independently associated with daily wage labor (adjusted odds ratio [aOR], 2.7; confidence interval [CI], 1.1-6.5;
conclusionAddressing structural and psychosocial barriers will be critical to improve TB treatment adherence in India. Urine isoniazid testing may help identify nonadherent patients to facilitate early intervention during treatment.
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