Evidence map›Paper›PMID 34250027›Full record

ArticleCase reports in nephrology and dialysis

Recurrence of Cryoglobulinemia Secondary to Hepatitis C in a Patient with HCV RNA (-) Negative in the Serum.

Małgorzata Sikorska-Wiśniewska, Katarzyna Sikorska, Anna Wróblewska, Tomasz Liberek, Agnieszka Perkowska-Ptasińska, Alicja Dębska-Ślizień

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in nephrology and dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Małgorzata Sikorska-WiśniewskaDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Katarzyna SikorskaDepartment of Tropical Medicine and Epidemiology, Medical University of Gdansk, Gdansk, Poland.
Anna WróblewskaDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk, Poland.
Tomasz LiberekDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Agnieszka Perkowska-PtasińskaDepartment of Transplantation Medicine and Nephrology, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
Alicja Dębska-ŚlizieńDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Gdańsk Medical University · PLMedical University of Warsaw · PLUniversity of Gdańsk · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus infection is associated with many extrahepatic manifestations such as mixed cryoglobulinemia (MC). Renal manifestation of HCV infection might present as cryo-positive membranoproliferative glomerulonephritis (MPGN). First-line therapy includes antiviral treatment as the underlying infection leads to formation of immune complexes. After introducing direct-acting antiviral agents (DAAs) cure rates of HCV infection increased. Sustained virologic response (SVR) is defined as the absence of HCV RNA in serum by a sensitive test performed 12 or 24 weeks after the end of antiviral treatment. Although HCV RNA is undetectable in the serum, it may be present in hepatocytes and peripheral blood mononuclear cells (occult HCV infection). However, the impact of DAA treatment on occult HCV infection is not clear. We report a case of recurrence of MC with MPGN and development of lymphoproliferative disorder 2 years after achieving SVR.

Indexed as

Extrahepatic HCV manifestationsMembranoproliferative glomerulonephritisMixed cryoglobulinemia

Identifiers

PMID34250027
PMCPMC8255656
OpenAlexW3167855311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.