Evidence map›Paper›PMID 34250019›Full record

ArticleFrontiers in molecular biosciences2021

Sex Differences in Tolerance to Delta-9-Tetrahydrocannabinol in Mice With Cisplatin-Evoked Chronic Neuropathic Pain.

Angela N Henderson-Redmond, LaTaijah C Crawford, Diana E Sepulveda, David E Hale, Julia J Lesperance, Daniel J Morgan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Impact of Soil Quality on Cannabinoid and Terpenoid Content ofJournal of medicinally active plants · 2025
    Article
  6. Article
  7. Article
  8. The Potential of Cannabichromene (CBC) as a Therapeutic Agent.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Mechanisms of cannabinoid tolerance.Biochemical pharmacology · 2023
    Review
  15. Cannabinoid Tolerance in S426A/S430A xThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Angela N Henderson-RedmondDepartment of Biomedical Sciences, Marshall University, Huntington, WV, United States.
LaTaijah C CrawfordDepartment of Biomedical Sciences, Marshall University, Huntington, WV, United States.
Diana E SepulvedaDepartment of Pharmacology, Penn State University College of Medicine, Hershey, PA, United States.
David E HaleDepartment of Anesthesiology and Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, United States.
Julia J LesperanceDepartment of Anesthesiology and Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, United States.
Daniel J MorganDepartment of Biomedical Sciences, Marshall University, Huntington, WV, United States.
Pennsylvania State University · USMarshall University · US

Funding

Mechanisms of cannabinoid toleranceR01DA044999 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GUINDON, JOSEE, MORGAN, DANIEL J · 2018 to 2022
$2.4M
Desensitization and downregulation of CB1 during cannabinoid toleranceK01DA037355 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MORGAN, DANIEL J · 2015 to 2017
$476k
NIDA NIH HHS K01 DA037355NIDA NIH HHS R01 DA044999
6 · The paper itself

Abstract

Tolerance to the pain-relieving effects of cannabinoids limits the therapeutic potential of these drugs in patients with chronic pain. Recent preclinical research with rodents and clinical studies in humans has suggested important differences between males and females in the development of tolerance to cannabinoids. Our previous work found that male mice expressing a desensitization resistant form (S426A/S430A) of the type 1 cannabinoid receptor (CB

Indexed as

cannabinoidschronic paincisplatinmicesex-differencestetrahydrocannabinoltolerance

Identifiers

PMID34250019
PMCPMC8267820
OpenAlexW3177470224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.