Evidence map›Paper›PMID 34249932›Full record

ArticleFrontiers in cell and developmental biology2021

Inactivation of the Euchromatic Histone-Lysine

Guillermo Urrutia, Thiago Milech de Assuncao, Angela J Mathison, Ann Salmonson, Romica Kerketta, Atefeh Zeighami, Timothy J Stodola, Volkan Adsay, Burcin Pehlivanoglu, Michael B Dwinell and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Increasing autophagy activity suppressesAmerican journal of cancer research · 2026
    Article
  4. Article
  5. Review
  6. Frontiers in genetics · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Guillermo UrrutiaDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Thiago Milech de AssuncaoDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Angela J MathisonDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Ann SalmonsonDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Romica KerkettaDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Atefeh ZeighamiDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Timothy J StodolaDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Volkan AdsayDepartment of Pathology, Koç University Hospital, Istanbul, Turkey.
Burcin PehlivanogluDepartment of Pathology, Adiyaman University Training and Research Hospital, Adiyaman, Turkey.
Michael B DwinellDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Michael T ZimmermannGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Juan L IovannaCentre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.
Raul UrrutiaDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Gwen LomberkDivision of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Medical College of Wisconsin · USAdıyaman University · TRCentre National de la Recherche Scientifique · FRKoç University · TR

Funding

ZINC FINGER GENES AND PANCREATIC CELL GROWTHR01DK052913 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI LOMBERK, GWEN, URRUTIA, RAUL A. · 1998 to 2023
$7.0M
Targeting Epigenomic Regulators at the Replication Fork in PDACR01CA247898 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI LOMBERK, GWEN · 2021 to 2025
$2.3M
Biased chemokine receptor signaling in cancer progressionR01CA226279 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MICHAEL B · 2019 to 2023
$1.9M
Novel Experimental Therapeutics for Pancreatic CancerR01CA178627 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI LOMBERK, GWEN · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA178627NCI NIH HHS R01 CA226279NCI NIH HHS R01 CA247898NIDDK NIH HHS R01 DK052913
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to its pathobiology. Here, we delineate the role of Euchromatic Histone-lysine

Indexed as

epigenomicsgene regulatory networkshistone methyltransferasespancreatic carcinomatumor microenvironment

Identifiers

PMID34249932
PMCPMC8261250
OpenAlexW3176318612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.