Evidence map›Paper›PMID 34249922›Full record

ArticleFrontiers in cell and developmental biology2021

A Functional Variant Rs492554 Associated With Congenital Heart Defects Modulates

Wenke Yang, Yi Li, Jun Bai, Tao You, Kang Yi, Dingxiong Xie, Xiaowei Zhang, Xiaodong Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Sestrin2 as a Protective Shield against Cardiovascular Disease.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wenke YangInstitute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Yi LiInstitute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Jun BaiInstitute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Tao YouDepartment of Cardiac Surgery, Gansu Provincial Hospital, Lanzhou, China.
Kang YiDepartment of Cardiac Surgery, Gansu Provincial Hospital, Lanzhou, China.
Dingxiong XieGansu Cardiovascular Institute, People's Hospital of Lanzhou City, Lanzhou, China.
Xiaowei ZhangDepartment of Hematology, Gansu Provincial Key Laboratory of Hematology, Second Hospital of Lanzhou University, Lanzhou, China.
Xiaodong XieInstitute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Lanzhou University · CNGansu Provincial Hospital · CNGansu Provincial Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia exposure is responsible for the high incidence of congenital heart defects (CHDs) in high-altitude areas, which is nearly 20 times higher than that in low-altitude areas. However, the genetic factors involved are rarely reported. Sestrin2 (

Indexed as

congenital heart defectshigh-altitudehypoxiars492554SESN2 genesingle nucleotide polymorphisms

Identifiers

PMID34249922
PMCPMC8260953
OpenAlexW3176784344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.