Evidence map›Paper›PMID 34249775›Full record

ArticleFrontiers in cellular and infection microbiology2021

Inflammatory Signatures of Pathogenic and Non-Pathogenic Leptospira Infection in Susceptible C3H-HeJ Mice.

Advait Shetty, Suman Kundu, Maria Gomes-Solecki

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. TLR4 competence and mouse models of sublethal leptospirosis.PLoS neglected tropical diseases · 2025
    Article
  5. Article
  6. Exposure to live saprophyticbioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Chemokine profile in the serum of patients with leptospirosis.Frontiers in cellular and infection microbiology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Hematogenous dissemination of pathogenic and non-pathogenicFrontiers in cellular and infection microbiology · 2022
    Article
  17. Article
  18. Article
  19. Screening of Surface-Exposed Lipoproteins ofFrontiers in microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Advait ShettyDepartment of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN, United States.
Suman KunduDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN, United States.
Maria Gomes-SoleckiDepartment of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN, United States.
University of Tennessee Health Science Center · US

Funding

Point of care assay for serodiagnosis of LeptospirosisR43AI136551 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2018 to 2019
$600k
Antibody isotyping for discrimination of disease stage and diagnosis of early Lyme disease.R43AI155211 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2020 to 2021
$594k
Role of TLR4 in persistent Leptospira infectionR21AI142129 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GOMES-SOLECKI, MARIA · 2019 to 2020
$418k
NIAID NIH HHS R21 AI142129NIAID NIH HHS R43 AI136551NIAID NIH HHS R43 AI155211
6 · The paper itself

Abstract

The exact global impact of leptospirosis is unknown due to inadequate surveillance systems in place in most low-income countries. In this study, we analyzed the differences in mouse inflammatory signatures involved in pathogenic versus non-pathogenic Leptospira recognition at 24h and 72h post infection. Injection of C3H-HeJ mice with non-pathogenic

Indexed as

LeptospiraLeptospira interrogansLeptospirosisAnimalsChemokinesImmunity, InnateMiceMice, Inbred C3HChemokineschemokinescytokinesflow cytometryimmune cellsL. biflexaLeptospirosisL. interrogansproteome array

Identifiers

PMID34249775
PMCPMC8264587
OpenAlexW3174583522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.