Evidence map›Paper›PMID 34249770›Full record

ArticleJournal of comorbidity

Multimorbidity at sea level and high-altitude urban and rural settings: The CRONICAS Cohort Study.

J Jaime Miranda, Antonio Bernabe-Ortiz, Robert H Gilman, Liam Smeeth, German Malaga, Robert A Wise, William Checkley, CRONICAS Cohort Study Group

Open access · goldAbstract read
In one paragraph

Article in Journal of comorbidity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Multimorbidity and its association with mental health in an adult population of Peru.Revista peruana de medicina experimental y salud publica · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Multimorbidity.Nature reviews. Disease primers · 2022
    Review
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  15. Article
  16. Article
  17. Article
  18. Multimorbidity matters in low and middle-income countries.Journal of multimorbidity and comorbidity
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

J Jaime MirandaCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0002-4738-5468
Antonio Bernabe-OrtizCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Robert H GilmanCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Liam SmeethCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
German MalagaCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Robert A WiseDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
William CheckleyProgram in Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
CRONICAS Cohort Study Group
Universidad Peruana Cayetano Heredia · PEJohns Hopkins University · US

Funding

Household Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1M
Latin America Treatment & Innovation Network in Mental Health (LATIN-MH)U19MH098780 · NIMH · FUNDACAO FACULDADE DE MEDICINA · PI ARAYA, RICARDO, MENEZES, PAULO ROSSI · 2013 to 2017
$2.7M
Launching a salt substitute to reduce blood pressure at the population level-PeruU01HL114180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2012 to 2016
$2.0M
Acute Lung Injury: Application of Novel Approaches to Longitudinal Data AnalysisR00HL096955 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHECKLEY, WILLIAM · 2011 to 2013
$723k
Building sustainable and innovative research in Cancer and Cardiovascular disease: Planning the design and development of the South American Center of Research Excellence to Counter NCDs (SACREN)P20CA217231 · NCI · INSTITUTO DE EFECTIVIDAD CLINICA Y SANIT · PI IRAZOLA, VILMA, MIRANDA, J JAIME · 2017 to 2018
$497k
Implementation of foot thermometry and SMS to prevent diabetic foot ulcerR21TW009982 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI MIRANDA, J JAIME · 2014 to 2015
$329k
Planning to Establish a Regional Center of NCD Research Training in PeruD71TW010877 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI MIRANDA, J JAIME · 2017 to 2017
$50k
FIC NIH HHS D71 TW010877FIC NIH HHS R21 TW009982NCI NIH HHS P20 CA217231NHLBI NIH HHS HHSN268200900033CNHLBI NIH HHS R00 HL096955NHLBI NIH HHS U01 HL114180NHLBI NIH HHS UM1 HL134590NIMH NIH HHS U19 MH098780Wellcome Trust
6 · The paper itself

Abstract

objectiveTo characterize the prevalence and clustering of multimorbidity in four diverse geographical settings in Peru.

methodsMultimorbidity, defined as having ≥2 chronic conditions, was studied in adults aged ≥35 years in four diverse settings in Peru: Lima, Tumbes, and urban and rural Puno. Six of these conditions (alcohol disorder, asthma, chronic obstructive pulmonary disease, depression, diabetes, and hypertension) were cataloged as objectively ascertained chronic conditions and paired in dyads to explore clusters of multimorbidity.

resultsWe analyzed data from 2890 adults, mean age 55.2 years, 49% males. Overall, 19.1% of participants had multimorbidity, ranging from 14.7% in semi-urban Tumbes to 22.8% in Lima. The dyads with the highest coexistence (approximately 20%) were observed in hypertension and diabetes in Tumbes, whereas the dyads with lowest coexistence (approximately 1%) were those involving asthma in all study sites. In terms of clusters, Tumbes showed a predominance of hypertension and diabetes, urban and rural Puno a predominance of depression and alcohol disorders, and Lima a higher degree of coexistence of all of the six conditions than in the other clusters.

conclusionMultimorbidity is common and the pattern of clusters is highly heterogeneous. The conditions to prioritize will vary in each setting.

Indexed as

epidemiologyMultimorbidityPeruurbanization

Identifiers

PMID34249770
PMCPMC8240099
OpenAlexW2983347375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.