Evidence map›Paper›PMID 34249735›Full record

ArticleFrontiers in oncology2021

Role of NRP1 in Bladder Cancer Pathogenesis and Progression.

Yang Dong, Wei-Ming Ma, Zhen-Duo Shi, Zhi-Guo Zhang, Jia-He Zhou, Yang Li, Shao-Qi Zhang, Kun Pang, Bi-Bo Li, Wen-da Zhang and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Neuropilin-1: A Multifaceted Target for Cancer Therapy.Current oncology (Toronto, Ont.) · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Pan-Cancer Analysis of the Prognostic and Immunological Role of SEMA7A.International journal of general medicine · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Yang DongDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Wei-Ming MaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Zhen-Duo ShiDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Zhi-Guo ZhangDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Jia-He ZhouDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Yang LiDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Shao-Qi ZhangMedical College of Soochow University, Suzhou, China.
Kun PangDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Bi-Bo LiNanjing University of Traditional Chinese Medicine, Nanjing, China.
Wen-da ZhangDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Tao FanDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Guang-Yuan ZhuDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Liang XueDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Rui LiDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Ying LiuDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Lin HaoDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Cong-Hui HanDepartment of Urology, Xuzhou Central Hospital, Xuzhou, China.
Xuzhou Central Hospital · CNJiangsu Normal University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common malignancy of the urinary system. In the current study, we investigated the function and mechanisms of Neuropilin-1 (NRP1), the co-receptor for vascular endothelial growth factor, in BC pathogenesis and progression. The expression of NRP1 was evaluated using data extracted from GEO and HPA databases and examined in BC cell lines. The effect on proliferation, apoptosis, angiogenesis, migration, and invasion of BC cells were validated after

Indexed as

apoptosisbladder cancerinvasionmigrationneovascularisationNRP1proliferation

Identifiers

PMID34249735
PMCPMC8261128
OpenAlexW3177496722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.