Evidence map›Paper›PMID 34249675›Full record

SynthesisFrontiers in oncology2021

The Impact of Preoperative Sarcopenia on Survival Prognosis in Patients Receiving Neoadjuvant Therapy for Esophageal Cancer: A Systematic Review and Meta-Analysis.

Sheng-Bo Jin, Zi-Bin Tian, Xue-Li Ding, Ying-Jie Guo, Tao Mao, Ya-Nan Yu, Kai-Xuan Wang, Xue Jing

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Effect of total gastrectomy on weight and body composition: A retrospective study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sheng-Bo JinDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Zi-Bin TianDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Xue-Li DingDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Ying-Jie GuoDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Tao MaoDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Ya-Nan YuDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Kai-Xuan WangDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.
Xue JingDepartment of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.
Qingdao University · CNAffiliated Hospital of Qingdao University · CNChanghai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia is a poor prognostic factor in patients with esophageal cancer (EC). It can be aggravated by neoadjuvant therapy (NAT) that improves the prognosis of patients with EC. Until now, the impact of preoperative sarcopenia on survival prognosis in patients receiving NAT for EC remains unclear.

methodsWe systematically researched relevant studies in the PubMed, EMBASE, Web of Science, the Cochrane Library databases up to March 8, 2020. Prevalence of sarcopenia before and after NAT, overall survival (OS) and disease-free survival (DFS) were collected for analysis. Finally, eleven cohort studies were included.

resultsPooled analysis indicated that preoperative sarcopenia was negatively associated with OS. (

conclusionsClinicians should strengthen the screening of preoperative sarcopenia in patients of EC both receiving NAT and older than 65 years and give active nutritional support to improve the prognosis of patients. SYSTEMATIC REVIEW REGISTRATION: International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY), identifier INPLASY202050057.

Indexed as

esophageal cancermeta-analysisneoadjuvant therapyprognosissarcopenia

Identifiers

PMID34249675
PMCPMC8260681
OpenAlexW3024527436

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.