Evidence map›Paper›PMID 34249663›Full record

ArticleAnesthesiology and pain medicine2021

Comparing the Effect of Lidocaine-Prilocaine Cream and Infiltrative Lidocaine on Overall Pain Perception During Thoracentesis and Abdominocentesis: A Randomized Clinical Trial.

Hanieh Halili, Reza Azizkhani, Saeid Tavakoli Garmaseh, Mohammad Saleh Jafarpisheh, Farhad Heydari, Babak Masoumi, Asieh Maghami Mehr

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05984264 (Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05984264 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis

TypeinterventionalSponsorAssiut UniversityRan2023 to 2023Enrolled118ConditionsPleural EffusionArmslidocaine 2.5% and prilocaine 2.5% cream in pain management before pleurocentesis.
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hanieh HaliliIsfahan University of Medical Sciences, Isfahan, Iran.
Reza AzizkhaniEmergency Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Saeid Tavakoli GarmasehIsfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Saleh JafarpishehInterventional Radiology Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Farhad HeydariEmergency Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Babak MasoumiEmergency Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Asieh Maghami MehrShiraz Payam Noor University, Shiraz, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute pain management is a core ethical commitment to medical practice. However, there is evidence to suggest that sometimes infiltrative lidocaine (IL) is not used prior to thoracentesis and abdominocentesis due to the belief that two needles cause greater pain than one. However, topical anesthetics like lidocaine-prilocaine cream (LPC) are painless, easy to use, and have less systemic side effects. Therefore, LPC can be a suitable substitute for medical procedures.

objectivesThis study was designed to compare the analgesic effects of LPC with IL in thoracentesis and abdominocentesis.

methodsPatients were divided into two study groups, including individuals seeing a physician for a thoracentesis (N = 36) and those seeing a physician for an abdominocentesis (N = 33). Patients were randomly assigned to the IL (N = 35) or LPC (N = 34) groups for diagnostic and/or therapeutic purposes. The IL group received 100 mg of 2% lidocaine 5 minutes prior to their procedure, whereas the LPC group received 2.5 g of lidocaine-prilocaine cream. The cream was spread over a 20 - 25 cm

resultsThe findings suggest a non-significant difference between overall pain perception in LPC and IL groups generally, as well as specifically in abdominocentesis and thoracentesis groups. Furthermore, the result remained the same after controlling for confounding variables. The number of attempts to perform successful abdominocentesis was significantly higher in the LPC than IL (P-value = 0.003) group but was not significant in the thoracentesis group (P-value = 0.131). The level of patient satisfaction in the LPC and IL groups were not significantly different (P-value > 0.05).

conclusionsOverall, LPC appears to be an appropriate alternative to IL in reducing pain during thoracentesis and abdominocentesis, but it seemed to increase unsuccessful medical procedure attempts.

Indexed as

LidocaineLidocaine-Prilocaine Drug CombinationPain ManagementParacentesisThoracentesis

Identifiers

PMID34249663
PMCPMC8256634
OpenAlexW3101961680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.