ArticleQuantitative imaging in medicine and surgery2021
Relationship between illness duration, corpus callosum changes, and sustained attention dysfunction in major depressive disorder.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis.Psychological medicine · 2025Pooled it
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Network-level disconnectivity tracks poststroke depressive symptom improvement.Psychiatry and clinical neurosciences · 2026Observational
- Gray and White matter microstructural alterations in major depressive disorder: a multi-center diffusion imaging study.Translational psychiatry · 2026Article
- Multi-omics analyses of the gut microbiome, fecal metabolome, and multimodal brain MRI reveal the role ofPsychological medicine · 2025Article
- Intermittent theta-burst stimulation alleviates hypoxia-ischemia-caused myelin damage and neurologic disability.Experimental neurology · 2024Article
- Treatment of vascular dementia in female rats with AV-001, an Angiopoietin-1 mimetic peptide, improves cognitive function.Frontiers in neuroscience · 2024Article
- Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa.Quantitative imaging in medicine and surgery · 2023Article
- Heterogeneous brain dynamic functional connectivity patterns in first-episode drug-naive patients with major depressive disorder.Human brain mapping · 2023Article
- White matter microstructure changes in adults with major depressive disorder: evidence from diffusion magnetic resonance imaging.BJPsych open · 2023Article
- Nanoparticulate MgHJournal of neuroinflammation · 2023Article
- Structural disconnection-based prediction of poststroke depression.Translational psychiatry · 2022Article
- Aberrant resting-state interhemispheric functional connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis.Neuroradiology · 2022Article
- Experience-dependent associations between distinct subtypes of childhood trauma and brain function and architecture.Quantitative imaging in medicine and surgery · 2022Article
- Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms.Frontiers in neuroscience · 2021Article
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Abstract
backgroundIllness duration is the main index of cumulative illness severity during depression progression. Corpus callosum (CC) damage is among the most replicated neurobiological findings in major depressive disorder (MDD). We aimed to investigate the nature and extent of the association between illness duration and CC changes.
methodsNinety-six MDD patients and 50 controls underwent diffusion and resting-state functional magnetic resonance imaging (fMRI). White matter micro-structure and inter-hemispheric functional connectivity were quantified by fractional anisotropy (FA) and voxel-mirrored homotopic connectivity (VMHC). The CC was reconstructed by tractography and divided into five sub-regions. The associations of illness duration with FA of each CC sub-region and voxel-wise VMHC were examined using correlation analyses. Also, we investigated the potential relationship between illness duration, CC changes, and clinical variables using mediation analyses.
resultsIn MDD patients, longer illness duration was selectively associated with lower FA of CC sub-regions 2 [partial correlation coefficient (pr) =-0.269, P=0.009] and 5 (pr=-0.296, P=0.004) as well as higher VMHC in the supplementary motor areas (pr=0.378, P<0.001), precuneus (pr=0.384, P<0.001), and lingual gyrus (pr=0.373, P<0.001) connected by the affected CC sub-regions. Further subgroup analyses demonstrated pronounced FA decrease and VMHC increase in patients with illness duration over 20 years relative to healthy controls (HC) and other patient subgroups with shorter illness durations. Moreover, lower FA of CC sub-regions 2 and 5 mediated the association between longer illness duration and more severe sustained attention dysfunction.
conclusionsThese findings provide evidence for compromised structure yet compensatory function of the CC with increasing depression illness duration, which may inform effective antidepressant treatment strategies at different disease stages.
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