Evidence map›Paper›PMID 34249600›Full record

ArticleIn silico pharmacology2021

Exploring the inhibitory potentials of

Temitope Isaac Adelusi, Misbaudeen Abdul-Hammed, Mukhtar Oluwaseun Idris, Oyedele Qudus Kehinde, Ibrahim Damilare Boyenle, Ukachi Chiamaka Divine, Ibrahim Olaide Adedotun, Ajayi Ayodeji Folorunsho, Oladipo Elijah Kolawole

Open access · greenAbstract read
In one paragraph

Article in In silico pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Phenolic Compounds fromAntibiotics (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Therapeutic Potential of Momordicine I fromInternational journal of molecular sciences · 2024
    Review
  5. Article
  6. PredictingIn silico pharmacology · 2024
    Article
  7. Article
  8. GCMS fingerprints and phenolic extracts ofJournal of Taibah University Medical Sciences · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Temitope Isaac AdelusiComputational Biology/Drug Discovery Laboratory, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Misbaudeen Abdul-HammedBiophysical and Computational Chemistry Unit, Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
Mukhtar Oluwaseun IdrisSchool of Life Sciences, University of Science and Technology of China, Hefei, Anhui China.
Oyedele Qudus KehindeComputational Biology/Drug Discovery Laboratory, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Ibrahim Damilare BoyenleComputational Biology/Drug Discovery Laboratory, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Ukachi Chiamaka DivineComputational Biology/Drug Discovery Laboratory, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Ibrahim Olaide AdedotunBiophysical and Computational Chemistry Unit, Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
Ajayi Ayodeji FolorunshoDepartment of Physiology, College of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
Oladipo Elijah KolawoleLaboratory of Molecular Biology, Immunology and Bioinformatics, Department of Microbiology, Adeleke University, Ede, Osun State Nigeria.
Ladoke Akintola University of Technology · NGAdeleke University · NGUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for Keap1 inhibitors as potential Nrf2 activator is a way of increasing the antioxidant status of the human cellular environ. In this research, we used in silico methods to investigate Keap1-kelch inhibitory potential of SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40203-021-00100-2.

Indexed as

Keap1Molecular dynamicsMolecular Mechanics-Poisson Boltzman Surface Area (g_MMPBSA)Momordica charantia

Identifiers

PMID34249600
PMCPMC8233444
OpenAlexW3173334961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.