Evidence map›Paper›PMID 34249451›Full record

ArticleAmerican journal of cancer research2021

Testosterone strongly enhances azoxymethane/dextran sulfate sodium-induced colorectal cancer development in C57BL/6 mice.

Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jeong Eun Yu, Heewon Nho, Eun Shin, Ha-Na Lee, Young-Joon Surh

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 21 citations in OpenAlex.

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  11. Obesity and Colorectal Cancer: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Chin-Hee SongDepartment of Internal Medicine, Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, South Korea.
Nayoung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, South Korea.
Ryoung Hee NamDepartment of Internal Medicine, Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, South Korea.
Soo In ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, South Korea.
Jeong Eun YuDepartment of Internal Medicine, Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, South Korea.
Heewon NhoDepartment of Internal Medicine, Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, South Korea.
Eun ShinDepartment of Pathology, Hallym University Dongtan Sacred Heart Hospital Hwaseong, Gyeonggi-do, South Korea.
Ha-Na LeeLaboratory of Immunology, Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration Silver Spring, MD 20993, USA.
Young-Joon SurhTumor Microenvironment Global Core Research Center, Seoul National University College of Pharmacy Seoul, South Korea.
Center for Drug Evaluation and Research · USSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is known to occur more frequently in males than in females, with sex hormones reportedly influencing the development. The purpose of the study was to investigate whether orchiectomy in C57BL/6 male mice reduces colorectal tumorigenesis and whether testosterone administration increases tumorigenesis after orchiectomy in an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. Clinical symptoms, including colitis and tumor incidence, were evaluated in the absence or presence of testosterone in AOM/DSS-treated male, as well as orchiectomized (ORX) male and female mice. The levels of serum testosterone and colonic myeloperoxidase, interleukin (IL)-1β, and IL-6 were measured by ELISA. Target mRNA expression was assessed by quantitative real-time PCR. Orchiectomy significantly diminished the AOM/DSS-induced colitis indices, including disease activity index, colon shortening, and histological severity at week 2, and decreased tumor numbers and incidence rates in the distal part of the colon increased following AOM/DSS administration at week 13; this reduction was reversed by testosterone supplementation. Furthermore, it was confirmed that the ELISA level (MPO and IL-1β) and the mRNA expression of the inflammatory mediators (COX-2 and iNOS) were maintained at high levels in the tumors of the testosterone-treated group compared with AOM/DSS groups. Interestingly, both endogenous and exogenous testosterone administrations were associated with tumor development (> 2 mm in size) and submucosal invasive cancer. Based on multivariate logistic regression analysis, testosterone was identified as a reasonable hazard factor for the progression of submucosal invasive cancer of the distal colon. In conclusion, endogenous and exogenous testosterone presented a stimulating effect on AOM/DSS-induced colitis and carcinogenicity.

Indexed as

AOM/DSS mouse modelcolitisColorectal cancerorchiectomysex differencesex hormonetestosterone propionate

Identifiers

PMID34249451
PMCPMC8263677
OpenAlexW3182242781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.