Evidence map›Paper›PMID 34249436›Full record

ArticleAmerican journal of cancer research2021

HP1BP3 promotes tumor growth and metastasis by upregulating miR-23a to target TRAF5 in esophageal squamous cell carcinoma.

Mingyi Shang, Li Weng, Shaoqiu Wu, Bingyan Liu, Xiang Yin, Zhongmin Wang, Aiwu Mao

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. METTL3-mediated mThe Kaohsiung journal of medical sciences · 2024
    Article
  8. Article
  9. International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mingyi ShangDepartment of Interventional Radiology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Li WengDepartment of Interventional Radiology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Shaoqiu WuDepartment of Interventional Radiology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Bingyan LiuDepartment of Interventional Radiology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Xiang YinDepartment of Interventional Radiology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Zhongmin WangClinical Research Center, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Aiwu MaoDepartment of Interventional Radiology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HP1BP3, an ubiquitously expressed nuclear protein belonging to the H1 histone family of proteins, plays an important role in cell growth and viability. Recently, it was reported that HP1BP3 exclusively regulates miRNA biogenesis by enhancing transcriptional miRNA processing. Although HP1BP3 has previously been implicated in common cancer types, the mechanistic functions and effects of HP1BP3 and its role in the prognosis of esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we report that ESCC tissues and cell lines show increased endogenous expression of HP1BP3. Knockdown of HP1BP3 in TE-1 cells significantly inhibited tumor growth and metastasis

Indexed as

esophageal cancerHP1BP3metastasismiR-23aTRAF5

Identifiers

PMID34249436
PMCPMC8263663
OpenAlexW3180272066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.