Evidence map›Paper›PMID 34249340›Full record

ArticleF1000Research2021

Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain.

Samuel J Toll, Fiona Qiu, Yifan Huang, Mark D Habgood, Katarzyna M Dziegielewska, Shuai Nie, Norman R Saunders

Open access · goldAbstract read
In one paragraph

Article in F1000Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Choroid Plexus Pathophysiology.Annual review of pathology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Samuel J Toll *Biochemistry & Pharmacology, University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0003-0323-9589
Fiona Qiu *Biochemistry & Pharmacology, University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0003-0642-1116
Yifan HuangBiochemistry & Pharmacology, University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0003-1060-3668
Mark D HabgoodBiochemistry & Pharmacology, University of Melbourne, Parkville, Victoria, 3010, Australia.
Katarzyna M DziegielewskaBiochemistry & Pharmacology, University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0002-0070-904X
Shuai NieMelbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute, University of Melbourne, Parkville, Victoria, 3010, Australia.
Norman R SaundersBiochemistry & Pharmacology, University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0001-6660-7639
Boston Children's Hospital · USGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnticonvulsantsValproic AcidAnimalsBrainFemaleLamotriginePlacentaPregnancyRatsAnticonvulsantsLamotrigineValproic Acidblood-brain barrierchoroid plexusCSFefflux mechanismsepilepsyfetusneonateplacenta.

Identifiers

PMID34249340
PMCPMC8207807.2
OpenAlexW3161994859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.